Epidermal Stem Cells Have the Potential to Assist in Healing Damaged Tissues
| Autor: | Matthew M. Stern, Antonio Manuel, Katie L. Grinnell, Jackie R. Bickenbach, Sathivel Chinnathambi |
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| Jazyk: | angličtina |
| Předmět: |
Wound Healing
Epidermis (botany) Somatic cell Stem Cells Clinical uses of mesenchymal stem cells Cell Differentiation Cell Separation Cell Biology Dermatology General Medicine Biology Cell biology Endothelial stem cell Mice Epidermal Cells Amniotic epithelial cells Immunology Animals Humans Stem cell Molecular Biology Stem Cell Transplantation Biotechnology Stem cell transplantation for articular cartilage repair Adult stem cell |
| Zdroj: | Journal of Investigative Dermatology Symposium Proceedings. (1):118-123 |
| ISSN: | 1087-0024 |
| DOI: | 10.1038/sj.jidsymp.5650009 |
| Popis: | Homeostasis of continuously renewing tissues, such as the epidermis, is maintained by somatic undifferentiated, self-renewing stem cells, which are thought to persist throughout life. Through a series of labeling experiments, we previously showed that stem cells from mouse skin did not divide often, but they did divide at a steady rate in vivo. Using our recently redefined sorting method, we isolated epidermal stem and transit amplifying (TA) cells from mouse skin. When injected into a developing blastocyst or into damaged tissues, the stem cells, but not the TA cells, could participate in the formation of new tissues. We hypothesize that all tissues contain reserved undifferentiated stem cells that are primed to react if needed. These reserve stem cells could restore the tissue in which they reside or they could be called upon to help restore another tissue that was severely damage. |
| Databáze: | OpenAIRE |
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