Pathophysiological Relevance of Renal Medullary Conditions on the Behaviour of Red Cells From Patients With Sickle Cell Anaemia
| Autor: | David C. Rees, Rasiqh Wadud, David C.-Y. Lu, John N. Brewin, John S. Gibson, Anke Hannemann |
|---|---|
| Přispěvatelé: | Apollo - University of Cambridge Repository |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty phosphatidylserine Physiology Cell urea Sickle cell nephropathy lcsh:Physiology Pathogenesis 03 medical and health sciences 0302 clinical medicine Internal medicine Physiology (medical) Renal medulla Medicine hypertonicity Acidosis Original Research Red Cell lcsh:QP1-981 business.industry hypoxia pH HbS polymerisation Hypoxia (medical) medicine.disease sickling 030104 developmental biology medicine.anatomical_structure Endocrinology 030220 oncology & carcinogenesis FOS: Biological sciences renal medulla medicine.symptom business Intracellular |
| Zdroj: | Frontiers in Physiology, Vol 12 (2021) Frontiers in Physiology |
| DOI: | 10.17863/cam.66578 |
| Popis: | Red cells from patients with sickle cell anaemia (SCA) contain the abnormal haemoglobin HbS. Under hypoxic conditions, HbS polymerises and causes red cell sickling, a rise in intracellular Ca2+ and exposure of phosphatidylserine (PS). These changes make sickle cells sticky and liable to lodge in the microvasculature, and so reduce their lifespan. The aim of the present work was to investigate how the peculiar conditions found in the renal medulla – hypoxia, acidosis, lactate, hypertonicity and high levels of urea – affect red cell behaviour. Results show that the first four conditions all increased sickling and PS exposure. The presence of urea at levels found in a healthy medulla during antidiuresis, however, markedly reduced sickling and PS exposure and would therefore protect against red cell adherence. Loss of the ability to concentrate urine, which occurs in sickle cell nephropathy would obviate this protective effect and may therefore contribute to pathogenesis. |
| Databáze: | OpenAIRE |
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