Different Effects of Estrogen and Progesterone on Experimental Atherosclerosis inFemale Versus Male Rabbits
| Autor: | Sybille Hanke, Alfred O. Mu¨ck, Vinzenz Hombach, Alexandra Muhic-Lohrer, Friedrich W. Schmahl, Rainer Haasis, Hartmut Hanke, Gerald Finking |
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| Rok vydání: | 1996 |
| Předmět: |
Male
Neointima medicine.medical_specialty Dose Arteriosclerosis medicine.drug_class Ovariectomy medicine.medical_treatment chemistry.chemical_compound Sex Factors Physiology (medical) Internal medicine Hydroxyprogesterones medicine Animals Progesterone Chemotherapy Lagomorpha Estradiol biology business.industry 17-alpha-Hydroxyprogesterone Estrogens DNA biology.organism_classification Cholesterol Endocrinology Bromodeoxyuridine chemistry Estrogen Ovariectomized rat Female Rabbits Cardiology and Cardiovascular Medicine business Orchiectomy Hormone |
| Zdroj: | Circulation. 94:175-181 |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/01.cir.94.2.175 |
| Popis: | Background The aim of the present study was to compare the effect of estrogen and progesterone on the development of experimental atherosclerosis in female versus male rabbits to assess possible sex-specific differences. Methods and Results A total of 32 female and 32 male New Zealand White rabbits were ovariectomized or castrated. In addition to a 0.5% cholesterol diet, the rabbits received estradiol alone (1 mg/kg body wt [BW] per week), progesterone alone (25 mg/kg BW per week), or combined estradiol-progesterone in these dosages during 12 weeks. Ovariectomized female and castrated male rabbits served as control groups without hormone treatment. Before excision of the vessels, bromodeoxyuridine labeling was performed to determine the extent of cellular proliferation in the atherosclerotic lesions. The aortic arch was analyzed immunohistologically and morphometrically. An inhibitory effect of estrogen on intimal plaque size was found in female rabbits compared with the ovariectomized control group (0.7±0.5 versus 3.7±2.5 mm 2 , P P 2 neointima; control group, 7.2±2.1% cellular proliferation and 2.9±1.2 mm 2 intimal thickening). Conclusions Our data suggest that the atheroprotective effect of estrogen is probably due to a mechanism that is present in female rabbits only. |
| Databáze: | OpenAIRE |
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