α‐Fetoprotein fragment synergizes with sorafenib to inhibit hepatoma cell growth and migration and promote the apoptosis

Autor:	Qiujiao Wang, Wei Li, Minni Zhang, Zijuan Zou, Xu Dong, Yi Chen, Junnv Xu, Mingyue Zhu, Mengsen Li, Bo Lin
Rok vydání:	2022
Předmět:	Carcinoma Hepatocellular Cell Line Tumor Liver Neoplasms Humans Molecular Medicine Apoptosis alpha-Fetoproteins Cell Biology Sorafenib Cell Proliferation
Zdroj:	Journal of Cellular and Molecular Medicine. 26:5426-5438
ISSN:	1582-4934 1582-1838
DOI:	10.1111/jcmm.17565
Popis:	Alpha fetoprotein (AFP) is associated with hepatocellular carcinoma (HCC) by stimulating the proliferation, metastasis and drug resistance. The application of AFP fragments to inhibit the malignant behaviours induced by AFP is a new strategy for the treatment of HCC. In an effort to design, screen and discover drugs, we attempted to express different human AFP fragments (AFP
Databáze:	OpenAIRE
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