Gestational Diabetes and T-cell (Th1/Th2/Th17/Treg) Immune Profile
| Autor: | Demetrios Rizos, Nikolaos-Dimitrios Panagopoulos, Katerina Psarra, Emmanouil Sifnaios, Nikolaos Vitoratos, Konstantinos Panoulis, George Creatsas, George Mastorakos |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty endocrine system diseases Offspring T cell T-Lymphocytes Systemic inflammation Gastroenterology T-Lymphocytes Regulatory General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Immune system Insulin resistance Th2 Cells Pregnancy Internal medicine medicine Humans Pharmacology business.industry nutritional and metabolic diseases Atopic dermatitis Th1 Cells medicine.disease Flow Cytometry Gestational diabetes Diabetes Gestational medicine.anatomical_structure C-Reactive Protein 030220 oncology & carcinogenesis Immune System Cytokines Th17 Cells Female medicine.symptom business Research Article |
| Zdroj: | In vivo (Athens, Greece). 33(1) |
| ISSN: | 1791-7549 |
| Popis: | Background/aim Gestational diabetes mellitus (GDM) is a common pregnancy complication, characterized by insulin resistance and low-grade systemic inflammation with a pro-inflammatory immune system response. Our objective was to study the peripheral Th1, Th2, Th17 and Treg response in GDM compared to normal pregnancy. Materials and methods Th1, Th2, Th17 and Treg subsets was determined by flow cytometry based on staining for specific intracellular cytokines, as well as C-reactive protein (CRP) and total IgE circulating levels. The health status of all offspring was also assessed 6 months post-delivery. Results A total of 49 Caucasian adult pregnant women were enrolled into a GDM (n=26) and Control (n=23) group. At the third trimester of pregnancy, the GDM group had a higher proportion of Th2, Th17 and Treg cells compared to control. Contrary to the control group, the GDM group exhibited no significant change in the Th1/Th2/Th17/Treg profile postpartum. Furthermore, higher circulating CRP and total IgE levels were noted in the GDM group compared to controls. At the 6-month post-delivery assessment, 30.8% of the offspring from the GDM group were found to have developed atopic dermatitis, food allergy or allergic proctocolitis compared to none from the control group. Conclusion Compared to an uncomplicated pregnancy, GDM exhibits a significantly different peripheral T-cell profile at the third pregnancy trimester characterized by higher proportion of Th2, Th17 and Treg cells which persist six months post-delivery, while the increased high sensitivity CRP (hsCRP) levels stressed the low-grade inflammatory profile of this disease. |
| Databáze: | OpenAIRE |
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