Molecular Profiling of Aggressive Lymphomas

Autor:	Anna Gazzola, Pier Paolo Piccaluga, Maria Rosaria Sapienza, Maria Antonella Laginestra, Stefano Pileri, Maura Rossi
Přispěvatelé:	Rossi M, Laginestra MA, Gazzola A, Sapienza MR, Pileri SA, Piccaluga PP.
Jazyk:	angličtina
Rok vydání:	2012
Předmět:	AGGRESSIVE LYMPHOMA business.industry Aggressive lymphoma Hematology Computational biology Review Article Bioinformatics hemic and lymphatic diseases Profiling (information science) Medicine Diseases of the blood and blood-forming organs RC633-647.5 Microrna profiling business Molecular entity
Zdroj:	Advances in Hematology, Vol 2012 (2012) Advances in Hematology
ISSN:	1687-9112 1687-9104
Popis:	In the last years, several studies of molecular profiling of aggressive lymphomas were performed. In particular, it was shown that DLBCL can be distinguished in two different entities according to GEP. Specifically, ABC and GCB subtypes were characterized by having different pathogenetic and clinical features. In addition, it was demonstrated that DLBCLs are distinct from BL. Indeed, the latter is a unique molecular entity. However, relevant pathological differences emerged among the clinical subtypes. More recently, microRNA profiling provided further information concerning BL-DLBCL distinction as well as for their subclassification. In this paper, the authors based on their own experience and the most updated literature review, the main concept on molecular profiling of aggressive lymphomas.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ccfdf737c360bc4e0da7fcd20c8a69 https://doaj.org/article/ddbeef592c18464483a06d7c9f852103 Zobrazit plný text záznamu Plný text