Cytotoxic Sterol Derivatives from a Marine Sponge Homaxinella sp
| Autor: | Chong-O. Lee, Song-Ja Bae, Jongki Hong, Jee H. Jung, Kwang Sik Im, Tayyab A. Mansoor |
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| Rok vydání: | 2005 |
| Předmět: |
Stereochemistry
medicine.medical_treatment Pharmaceutical Science Antineoplastic Agents Stereoisomerism Fractionation Pharmacognosy Analytical Chemistry Steroid Drug Discovery Tumor Cells Cultured medicine Animals Humans Nuclear Magnetic Resonance Biomolecular Ovarian Neoplasms Pharmacology chemistry.chemical_classification Korea Molecular Structure biology Organic Chemistry Biological activity biology.organism_classification Sterol Porifera Sterols Sponge Complementary and alternative medicine chemistry Biochemistry Molecular Medicine Female lipids (amino acids peptides and proteins) Drug Screening Assays Antitumor Lactone |
| Zdroj: | Journal of Natural Products. 68:331-336 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np0496690 |
| Popis: | A bioactivity-guided fractionation of a marine sponge Homaxinella sp. has led to the isolation of three new (1-3) highly degraded sterols and four new 6-O-alkylated (6-9) sterols, along with known sterol derivatives. The degraded sterols (1-5) belong to the class incisterols, previously isolated from the marine sponge Dictyonella incisa. Mainly NMR and MS spectroscopic analyses established the gross structures of the new compounds. The relationship between the stereoisomerism of the side chain and HPLC retention time has also been discussed. The compounds were tested against a panel of five human solid tumor cell lines, and especially the degraded sterols (1-4) displayed significant cytotoxicity. |
| Databáze: | OpenAIRE |
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