Association of Cardiometabolic Multimorbidity With Mortality

Autor: Richard F. Gillum, Beatriz L. Rodriguez, Stephen Kaptoge, Gilles R. Dagenais, Barbara V. Howard, Eric J. Brunner, Sylvia Wassertheil-Smoller, Aulikki Nissinen, Jackie F. Price, Hiroyasu Iso, Narinder Bansal, Peter Willeit, Emanuele Di Angelantonio, Lars Wilhelmsen, Angela M. Wood, Cecilia Björkelund, W. M. Monique Verschuren, Naveed Sattar, Ronan Roussel, Pei Gao, Ralph B. D'Agostino, Altan Onat, Maurizio Trevisan, Bu B. Yeap, Elizabeth L M Barr, Matthew Knuiman, Yvonne T. van der Schouw, Linda M. O’Keeffe, Adam S. Butterworth, Dorothea Nagel, J. Wouter Jukema, Coen D.A. Stehouwer, John Danesh, Wayne D. Rosamond, Bruce M. Psaty, Maryam Kavousi, Marcus Dörr, Gunnar Engström, Veikko Salomaa, Shinichi Sato, Paul J. Nietert, Pim van der Harst, Edoardo Casiglia, Karina W. Davidson, Dorly J. H. Deeg, Bo Hedblad, John Gallacher, Mark Woodward, Debbie A Lawlor, Sanne A.E. Peters, Annette Peters, Lewis H. Kuller, Robert B. Wallace, Lise Lund Håheim, Leon A. Simons, Randi Selmer, Philippe Amouyel, Kurt Svärdsudd, Gerd Assmann, Nicholas J. Wareham, Stefan Kiechl, Maarten J.G. Leening, Simon G. Thompson, Lennart Welin, Simona Giampaoli, Hermann Brenner, Kay-Tee Khaw, Elizabeth Selvin, Inger Njølstad, Oscar H. Franco, Tom W. Meade, Jukka T. Salonen, Frank B. Hu, Daniel F. Freitag, Stephen Burgess, Lisa Pennells, Chiara Donfrancesco, Johan Sundström, Elizabeth Barrett-Connor, Carlos J. Crespo, Eric A. Whitsel, Annika Rosengren, Jussi Kauhanen, Carole L. Hart, Børge G. Nordestgaard, Daan Kromhout, David Wormser, Cyrus Cooper
Přispěvatelé: Di Angelantonio, Emanuele [0000-0001-8776-6719], Kaptoge, Stephen [0000-0002-1155-4872], Butterworth, Adam [0000-0002-6915-9015], Bansal, Narinder [0000-0002-6925-1719], Wood, Angela [0000-0002-7937-304X], Burgess, Stephen [0000-0001-5365-8760], Pennells, Lisa [0000-0002-8594-3061], Khaw, Kay-Tee [0000-0002-8802-2903], Wareham, Nicholas [0000-0003-1422-2993], Thompson, Simon [0000-0002-5274-7814], Danesh, John [0000-0003-1158-6791], Apollo - University of Cambridge Repository, EMGO+ - Lifestyle, Overweight and Diabetes, Epidemiology and Data Science, EMGO - Lifestyle, overweight and diabetes
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Adult
Male
medicine.medical_specialty
Myocardial Infarction
Comorbidity
030204 cardiovascular system & hematology
Research Support
Article
03 medical and health sciences
0302 clinical medicine
Life Expectancy
SDG 3 - Good Health and Well-being
Risk Factors
Internal medicine
Diabetes mellitus
Epidemiology
medicine
Diabetes Mellitus
Journal Article
Humans
Life Science
Cardiac and Cardiovascular Systems
030212 general & internal medicine
Myocardial infarction
Mortality
Non-U.S. Gov't
Stroke
Human Nutrition & Health
Aged
business.industry
Mortality rate
Research Support
Non-U.S. Gov't
Hazard ratio
Humane Voeding & Gezondheid
epidemiology [Diabetes Mellitus]
General Medicine
Female
Middle Aged
medicine.disease
epidemiology [Myocardial Infarction]
3. Good health
Cohort
Life expectancy
Medical emergency
business
epidemiology [Stroke]
Zdroj: Di Angelantonio, E, Kaptoge, S, Wormser, D, Willeit, P, Butterworth, A S, Bansal, N, O'Keeffe, L M, Gao, P, Wood, A M, Burgess, S, Freitag, D F, Pennells, L, Peters, S A, Hart, C L, Haheim, L L, Gillum, R F, Nordestgaard, B G, Psaty, B M, Yeap, B B, Knuiman, M W, Nietert, P J, Kauhanen, J, Salonen, J T, Kuller, L H, Simons, L A, van der Schouw, Y T, Barrett-Connor, E, Selmer, R, Crespo, C J, Rodriguez, B, Verschuren, W M M, Salomaa, V, Svardsudd, K, van der Harst, P, Bjorkelund, C, Wilhelmsen, L, Wallace, R B, Brenner, H, Amouyel, P, Barr, E L M, Iso, H, Onat, A, Trevisan, M, D'Agostino, R B, Cooper, C, Kavousi, M, Welin, L, Roussel, R, Hu, F B, Sato, S, Davidson, K W, Howard, B V, Leening, M, Rosengren, A, Dorr, M, Deeg, D, Kiechl, S, Stehouwer, C D A, Nissinen, A, Giampaoli, S, Donfrancesco, C, Kromhout, D, Price, J F, Peters, A, Meade, T W, Casiglia, E, Lawlor, D A, Gallacher, J, Nagel, D, Franco, O H, Assmann, G, Dagenais, G R, Jukema, J W, Sundstrom, J, Woodward, M, Brunner, E J, Khaw, K T, Wareham, N J, Whitsel, E A, Njolstad, I, Hedblad, B, Wassertheil-Smoller, S, Engstrom, G, Rosamond, W D, Selvin, E, Sattar, N, Thompson, S G & Danesh, J 2015, ' Association of Cardiometabolic Multimorbidity With Mortality ', JAMA, vol. 314, no. 1, pp. 52-60 . https://doi.org/10.1001/jama.2015.7008
JAMA: The Journal of the American Medical Association 314 (2015) 1
JAMA-The Journal of The American Medical Association, 314(1), 52. American Medical Association
JAMA, 314(1), 52-60. American Medical Association
JAMA: The Journal of the American Medical Association; 314(1), pp 52-60 (2015)
JAMA: The Journal of the American Medical Association, 314(1), 52-60
ISSN: 0098-7484
1538-3598
DOI: 10.1001/jama.2015.7008
Popis: IMPORTANCE: The prevalence of cardiometabolic multimorbidity is increasing. OBJECTIVE: To estimate reductions in life expectancy associated with cardiometabolic multimorbidity. DESIGN, SETTING, AND PARTICIPANTS: Age- and sex-adjusted mortality rates and hazard ratios (HRs) were calculated using individual participant data from the Emerging Risk Factors Collaboration (689 300 participants; 91 cohorts; years of baseline surveys: 1960-2007; latest mortality follow-up: April 2013; 128 843 deaths). The HRs from the Emerging Risk Factors Collaboration were compared with those from the UK Biobank (499 808 participants; years of baseline surveys: 2006-2010; latest mortality follow-up: November 2013; 7995 deaths). Cumulative survival was estimated by applying calculated age-specific HRs for mortality to contemporary US age-specific death rates. EXPOSURES: A history of 2 or more of the following: diabetes mellitus, stroke, myocardial infarction (MI). MAIN OUTCOMES AND MEASURES: All-cause mortality and estimated reductions in life expectancy. RESULTS: In participants in the Emerging Risk Factors Collaboration without a history of diabetes, stroke, or MI at baseline (reference group), the all-cause mortality rate adjusted to the age of 60 years was 6.8 per 1000 person-years. Mortality rates per 1000 person-years were 15.6 in participants with a history of diabetes, 16.1 in those with stroke, 16.8 in those with MI, 32.0 in those with both diabetes and MI, 32.5 in those with both diabetes and stroke, 32.8 in those with both stroke and MI, and 59.5 in those with diabetes, stroke, and MI. Compared with the reference group, the HRs for all-cause mortality were 1.9 (95% CI, 1.8-2.0) in participants with a history of diabetes, 2.1 (95% CI, 2.0-2.2) in those with stroke, 2.0 (95% CI, 1.9-2.2) in those with MI, 3.7 (95% CI, 3.3-4.1) in those with both diabetes and MI, 3.8 (95% CI, 3.5-4.2) in those with both diabetes and stroke, 3.5 (95% CI, 3.1-4.0) in those with both stroke and MI, and 6.9 (95% CI, 5.7-8.3) in those with diabetes, stroke, and MI. The HRs from the Emerging Risk Factors Collaboration were similar to those from the more recently recruited UK Biobank. The HRs were little changed after further adjustment for markers of established intermediate pathways (eg, levels of lipids and blood pressure) and lifestyle factors (eg, smoking, diet). At the age of 60 years, a history of any 2 of these conditions was associated with 12 years of reduced life expectancy and a history of all 3 of these conditions was associated with 15 years of reduced life expectancy. CONCLUSIONS AND RELEVANCE: Mortality associated with a history of diabetes, stroke, or MI was similar for each condition. Because any combination of these conditions was associated with multiplicative mortality risk, life expectancy was substantially lower in people with multimorbidity.
Databáze: OpenAIRE
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