The Human Microbiota and Obesity: A Literature Systematic Review of In Vivo Models and Technical Approaches
| Autor: | Noel Noé Franco-Arroyo, Juan Manuel Viveros-Paredes, Rocío Ivette López-Roa, Lucrecia Carrera-Quintanar, Adelaida Sara Minia Zepeda-Morales, Daniel Ortuño-Sahagún |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
obesity Computational biology Review Gut flora Catalysis Inorganic Chemistry lcsh:Chemistry 03 medical and health sciences Animal model microbiota Medicine Animals Humans human Physical and Theoretical Chemistry Metabolic disease Molecular Biology lcsh:QH301-705.5 Spectroscopy Data source Inflammation biology business.industry animal model Organic Chemistry Human microbiome General Medicine Fecal bacteriotherapy medicine.disease biology.organism_classification Obesity Computer Science Applications Gastrointestinal Microbiome inflammatory disease 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 business Dysbiosis |
| Zdroj: | International Journal of Molecular Sciences, Vol 19, Iss 12, p 3827 (2018) International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| Popis: | Obesity is a noncommunicable disease that affects a considerable part of humanity. Recently, it has been recognized that gut microbiota constitutes a fundamental factor in the triggering and development of a large number of pathologies, among which obesity is one of the most related to the processes of dysbiosis. In this review, different animal model approaches, methodologies, and genome scale metabolic databases were revisited to study the gut microbiota and its relationship with metabolic disease. As a data source, PubMed for English-language published material from 1 January 2013, to 22 August 2018, were screened. Some previous studies were included if they were considered classics or highly relevant. Studies that included innovative technical approaches or different in vivo or in vitro models for the study of the relationship between gut microbiota and obesity were selected after a 16-different-keyword exhaustive search. A clear panorama of the current available options for the study of microbiota’s influence on obesity, both for animal model election and technical approaches, is presented to the researcher. All the knowledge generated from the study of the microbiota opens the possibility of considering fecal transplantation as a relevant therapeutic alternative for obesity and other metabolic disease treatment. |
| Databáze: | OpenAIRE |
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