Reconsolidation and extinction: Using epigenetic signatures to challenge conventional wisdom

Autor: Marcelo A. Wood, K. Matthew Lattal, Thekla J. Hemstedt
Rok vydání: 2016
Předmět:
0301 basic medicine
Medical and Health Sciences
Epigenesis
Genetic
Extinction
Psychological
Histones
Behavioral Neuroscience
0302 clinical medicine
Conditioning
Psychological
DNA methylation
Acetylation
Extinction
Fear
Post-Traumatic Stress Disorder (PTSD)
Anxiety Disorders
Mental Health
Histone acetylation
Anxiety
Epigenetics
Memory consolidation
medicine.symptom
Psychology
Fear memory
Cognitive Neuroscience
Experimental and Cognitive Psychology
Conventional wisdom
Behavioral Science & Comparative Psychology
Affect (psychology)
Basic Behavioral and Social Science
Article
03 medical and health sciences
Genetic
Memory
Intervention (counseling)
Behavioral and Social Science
Genetics
medicine
Animals
Memory Consolidation
Psychology and Cognitive Sciences
Neurosciences
Reconsolidation
Extinction (psychology)
DNA Methylation
Brain Disorders
030104 developmental biology
Psychological
Mind and Body
Neuroscience
030217 neurology & neurosurgery
Epigenesis
Conditioning
Zdroj: Neurobiology of learning and memory, vol 142, iss Pt A
ISSN: 1095-9564
Popis: Epigenetic mechanisms have the potential to give rise to lasting changes in cell function that ultimately can affect behavior persistently. This concept is especially interesting with respect to fear reconsolidation and fear memory extinction. These two behavioral approaches are used in the laboratory to investigate how fear memory can be attenuated, which becomes important when searching for therapeutic intervention to treat anxiety disorders and post-traumatic stress disorder. Here we review the role of several key epigenetic mechanisms in reconsolidation and extinction of learned fear and their potential to persistently alter behavioral responses to conditioned cues. We also briefly discuss how epigenetic mechanisms may establish persistent behaviors that challenge our definitions of extinction and reconsolidation.
Databáze: OpenAIRE
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