Central Nervous System Remyelination: Roles of Glia and Innate Immune Cells
| Autor: | Khalil S. Rawji, Charbel S. Baaklini, Madelene F. S. Ho, Jason R. Plemel, Greg J. Duncan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
microglia Inflammation Review Biology lcsh:RC321-571 03 medical and health sciences Cellular and Molecular Neuroscience Myelin 0302 clinical medicine Immune system medicine Remyelination Molecular Biology lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Innate immune system Microglia Multiple sclerosis aging oligodendrocyte progenitor cells astrocytes medicine.disease Oligodendrocyte 3. Good health 030104 developmental biology medicine.anatomical_structure remyelination nervous system medicine.symptom Neuroscience 030217 neurology & neurosurgery oligodendrocyte white matter disease |
| Zdroj: | Frontiers in Molecular Neuroscience, Vol 12 (2019) Frontiers in Molecular Neuroscience |
| ISSN: | 1662-5099 |
| DOI: | 10.3389/fnmol.2019.00225/full |
| Popis: | In diseases such as multiple sclerosis (MS), inflammation can injure the myelin sheath that surrounds axons, a process known as demyelination. The spontaneous regeneration of myelin, called remyelination, is associated with restoration of function and prevention of axonal degeneration. Boosting remyelination with therapeutic intervention is a promising new approach that is currently being tested in several clinical trials. The endogenous regulation of remyelination is highly dependent on the immune response. In this review article, we highlight the cell biology of remyelination and its regulation by innate immune cells. For the purpose of this review, we discuss the roles of microglia, and also astrocytes and oligodendrocyte progenitor cells (OPCs) as they are being increasingly recognized to have immune cell functions. |
| Databáze: | OpenAIRE |
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