ISG15 uncut: Dissecting enzymatic and non-enzymatic functions of USP18 in vivo
| Autor: | Lars Ketscher, Klaus-Peter Knobeloch |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_treatment
Immunology Biochemistry Virus Mice Interferon In vivo medicine Immunology and Allergy Animals STAT1 Molecular Biology Ubiquitins chemistry.chemical_classification Protease biology Chemistry Hematology ISG15 Isopeptidase activity Enzyme biology.protein Cytokines Protein Processing Post-Translational Ubiquitin Thiolesterase medicine.drug |
| Zdroj: | Cytokine. 76(2) |
| ISSN: | 1096-0023 |
| Popis: | Posttranslational protein modification by ISG15 plays an important role in antiviral defense. We selectively inactivated the ISG15 isopeptidase activity of USP18 in mice. Increased ISGylation was accompanied by enhanced viral resistance without causing detrimental side effects suggesting that USP18 protease inhibition might be a suitable antiviral strategy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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