Effect of the revised CDC case definition of AIDS on the number of AIDS cases in the Sydney AIDS Prospective Study
| Autor: | David A. Cooper, John M. Kaldor, Brett Tindall, T. Sharkey |
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| Rok vydání: | 1992 |
| Předmět: |
CD4-Positive T-Lymphocytes
Male Pediatrics medicine.medical_specialty Asymptomatic Cohort Studies Leukocyte Count Acquired immunodeficiency syndrome (AIDS) Risk Factors Surveys and Questionnaires HIV Seropositivity Internal Medicine medicine Humans Prospective Studies Prospective cohort study Acquired Immunodeficiency Syndrome business.industry Incidence Public health Australia medicine.disease United States Case definition Cohort Immunology Viral disease Centers for Disease Control and Prevention U.S medicine.symptom business Hiv disease |
| Zdroj: | Australian and New Zealand Journal of Medicine. 22:369-373 |
| ISSN: | 0004-8291 |
| DOI: | 10.1111/j.1445-5994.1992.tb02150.x |
| Popis: | We sought to evaluate the potential impact of a proposed revision in the case definition of acquired immunodeficiency syndrome (AIDS) (from a clinical case definition to one also including subjects with HIV infection who have an absolute number of peripheral CD4 + cells of less than 200 times 106/L) among 512 HIV-seropositive homosexual/bisexual who were reviewed between 1984 and 1991. According to the current case definition, 151 (30%) of 512 at-risk subjects developed AIDS between 1984 and August 1, 1991. Of the 361 at-risk subjects who were not classified as AIDS by the current definition, 47 (13%; 95% CI 9 – 17%) were classified as AIDS according to the revised definition. The median time to development of AIDS according to the revised definition was 288 weeks and that according to the current definition was 338 weeks. Data on clinical status were available for 34 of the new cases at the time of their diagnosis according to the proposed case definition: 16 (47%) of these were asymptomatic, 10 (29%) had persistent generalised lymphadenopathy and eight had minor infectious diseases. Of the 151 cases diagnosed according to the current definition, 78 (52%) had an antecedent CD4 + cell count that met the criteria for AIDS under the revised definition a median of 59 weeks before their diagnosis according to the current definition. These data indicate an appreciable increase in the number of cases of AIDS in this cohort when the revised case definition was applied. These findings have important implications for the surveillance, and for the clinical monitoring and treatment, of patients with HIV disease in Australia. |
| Databáze: | OpenAIRE |
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