IgG4-negative pituitary inflammatory pseudotumor with sphenoidal involvement resembling a macroadenoma
| Autor: | Georgios Alexopoulos, Kate Schwetye, Jeroen Coppens, Maheen Khan, Mohammad Almajali, Fawwaz Almajali, Philippe Mercier |
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| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty business.industry fungi food and beverages General Medicine Disease stomatognathic diseases 03 medical and health sciences 0302 clinical medicine Pituitary mass 030220 oncology & carcinogenesis Immunoglobulin g4 parasitic diseases medicine Etiology Inflammatory pseudotumor Surgery Neurology (clinical) business Inflammatory pseudotumors 030217 neurology & neurosurgery |
| Zdroj: | British journal of neurosurgery. |
| ISSN: | 1360-046X |
| Popis: | Inflammatory pseudotumors (IPTs) are rare benign conditions of unknown etiology that can affect any part of the body. IPTs are most commonly associated with Immunoglobulin G4 (IgG4)-related disease. Central nervous system IPTs, especially with pituitary involvement, are even rarer entities. The presence of an IgG4-negative pituitary IPT with simultaneous extracranial involvement has not been reported.We present the case of a 41-year-old female with past medical history of rheumatoid arthritis and a diagnosis of pituitary IPT with coexisting sphenoidal (extracranial) involvement mimicking a pituitary macroadenoma at presentation. The patient underwent multiple consecutive biopsies, and an extensive workup prior to establishing the diagnosis. Laboratory work-up showed normal serum IgG4 and unremarkable liver function tests.Pituitary lesions with simultaneous sphenoidal involvement in patients with IgG4-negative systemic inflammatory disease should raise the clinical suspicion for intracranial IPTs, as these tumors can mimic aggressive counterparts causing adjacent bony erosion, and local invasion. |
| Databáze: | OpenAIRE |
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