Synergistic cytotoxic and anti-invasive effects of mitoxantrone and triterpene saponins from Lysimachia ciliata on human prostate cancer cells
| Autor: | Katarzyna Wójcik-Pszczoła, Dawid Wnuk, Irma Podolak, Jarosław Czyż, Marta Michalik, Kamil Piska, Anna Łabędź-Masłowska, Ewa Kowolik, Elżbieta Pękala, Paulina Koczurkiewicz |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male medicine.medical_treatment proliferation Saponin Pharmaceutical Science Biology Pharmacology cell motility mitoxantrone Analytical Chemistry 03 medical and health sciences Prostate cancer 0302 clinical medicine Cell Line Tumor Drug Discovery medicine Cytotoxic T cell Humans Cytotoxicity Lysimachia ciliata Primulaceae chemistry.chemical_classification Chemotherapy Mitoxantrone Organic Chemistry apoptosis Prostatic Neoplasms Biological activity triterpene saponins Saponins medicine.disease prostate cancer Antineoplastic Agents Phytogenic Triterpenes 030104 developmental biology Complementary and alternative medicine chemistry 030220 oncology & carcinogenesis Cancer cell Molecular Medicine medicine.drug |
| Popis: | Triterpene saponins are secondary metabolites typical for higher plants. They possess a wide range of pharmaceutical and biological activities. These include anti-inflammatory, vasoprotective, expectorant, and antitumor properties. In particular, the ability of saponins to enhance the cytotoxicity of chemotherapeutic drugs has opened new perspectives for their application in combined cancer chemotherapy. In this study, the biological activity of the saponin fraction isolated from Lysimachia ciliata (denoted as CIL-1/2) was evaluated to assess its chemosensitizing activity in prostate cancer cell lines (DU-145, PC-3). No cytotoxic or cytostatic effect of the CIL-1/2 fraction administered at the concentration of 0.5 µg/mL was observed. In contrast, cocktails of CIL-1/2 and mitoxantrone (a drug commonly used in prostate cancer therapy) exerted synergistic cytostatic and proapoptotic effects. Furthermore, the synergy of proapoptotic activities of the analyzed cocktails is accompanied by their synergistic effects on prostate cancer cell movement and invasiveness. The significantly weaker impact of this cocktail on normal prostate cells additionally adds to the significance of our data and confirms that the CIL-1/2 fraction might be considered a potent adjuvant for prostate cancer chemotherapy. |
| Databáze: | OpenAIRE |
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