Poor outcome in hypoxic endometrial carcinoma is related to vascular density

Autor: Maria Santacana, Marc P.L.M. Snijders, Antonio Gil-Moreno, Xavier Matias-Guiu, Jutta Huvila, Johan P. Peters, Frédéric Amant, Johan Bulten, Camilla Krakstad, Eva Colas, Ingfrid S. Haldorsen, Martijn Arts, Willem Jan van Weelden, P.F.J.W. Rijken, Eva Jandáková, Peter Bronsert, Koen Van de Vijver, Gemma Mancebo, Heidi V.N. Küsters-Vandevelde, Martin Koskas, Lubos Minar, Johanna M.A. Pijnenborg, Vít Weinberger, Saskia van den Berg-van Erp, Marc Hirschfeld, Leon F.A.G. Massuger, Johan Bussink, Jone Trovik, Casper Reijnen, Armando Reques
Přispěvatelé: ENITEC consortium, ARD - Amsterdam Reproduction and Development, CCA - Cancer biology and immunology, Obstetrics and Gynaecology
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Oncology
Cancer Research
Angiogenesis
CD34
ANGIOGENESIS
TUMOR HYPOXIA
Neovascularization
Prognostic markers
0302 clinical medicine
Endometrial cancer
PROGNOSTIC-SIGNIFICANCE
Medicine
SPACE INVASION
MICROVESSEL DENSITY
INDUCIBLE FACTOR-1
Aged
80 and over
Women's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17]
Neovascularization
Pathologic
Hazard ratio
Middle Aged
Cell Hypoxia
Women's cancers Radboud Institute for Health Sciences [Radboudumc 17]
030220 oncology & carcinogenesis
Female
medicine.symptom
Life Sciences & Biomedicine
Rare cancers Radboud Institute for Health Sciences [Radboudumc 9]
Adult
EXPRESSION
medicine.medical_specialty
CARBONIC-ANHYDRASE-IX
Article
03 medical and health sciences
All institutes and research themes of the Radboud University Medical Center
Internal medicine
Carcinoma
Humans
BREAST-CANCER
Carbonic Anhydrase IX
Aged
Science & Technology
Tumor hypoxia
business.industry
Proportional hazards model
LYMPH-NODE METASTASIS
Hypoxia (medical)
medicine.disease
Endometrial Neoplasms
business
Zdroj: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
British journal of cancer, 120(11), 1037-1044. Nature Publishing Group
British Journal of Cancer, 120, 1037-1044
British Journal of Cancer
Repositorio Abierto de la UdL
Universitad de Lleida
British Journal of Cancer, 120, 11, pp. 1037-1044
ISSN: 1037-1044
0007-0920
Popis: BACKGROUND: Identification of endometrial carcinoma (EC) patients at high risk of recurrence is lacking. In this study, the prognostic role of hypoxia and angiogenesis was investigated in EC patients. METHODS: Tumour slides from EC patients were stained by immunofluorescence for carbonic anhydrase IX (CAIX) as hypoxic marker and CD34 for assessment of microvessel density (MVD). CAIX expression was determined in epithelial tumour cells, with a cut-off of 1%. MVD was assessed according to the Weidner method. Correlations with disease-specific survival (DSS), disease-free survival (DFS) and distant disease-free survival (DDFS) were calculated using Kaplan-Meier curves and Cox regression analysis. RESULTS: Sixty-three (16.4%) of 385 ECs showed positive CAIX expression with high vascular density. These ECs had a reduced DSS compared to tumours with either hypoxia or high vascular density (log-rank p = 0.002). Multivariable analysis showed that hypoxic tumours with high vascular density had a reduced DSS (hazard ratio [HR] 3.71, p = 0.002), DDFS (HR 2.68, p = 0.009) and a trend for reduced DFS (HR 1.87, p = 0.054). CONCLUSIONS: This study has shown that adverse outcome in hypoxic ECs is seen in the presence of high vascular density, suggesting an important role of angiogenesis in the metastatic process of hypoxic EC. Differential adjuvant treatment might be indicated for these patients. ispartof: BRITISH JOURNAL OF CANCER vol:120 issue:11 pages:1037-1044 ispartof: location:England status: published
Databáze: OpenAIRE
Externí odkaz: