Impact of asthma on bronchiectasis severity and risk of exacerbations
| Autor: | Claudia Crimi, Raffaele Campisi, Nunzio Crimi, Enrico Heffler, Francesca Puggioni, Giovanni Paoletti, Giulia Cacopardo, Sebastian Ferri |
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| Rok vydání: | 2020 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Exacerbation viruses macromolecular substances Disease comorbidities Severity of Illness Index 03 medical and health sciences exacerbation 0302 clinical medicine immune system diseases Internal medicine medicine Humans Immunology and Allergy 030212 general & internal medicine Asthma Bronchiectasis business.industry Sputum respiratory system medicine.disease Comorbidity respiratory tract diseases Eosinophils 030228 respiratory system inflammation Immunoglobulin G Pediatrics Perinatology and Child Health business |
| Zdroj: | Journal of Asthma. 59:469-475 |
| ISSN: | 1532-4303 0277-0903 |
| DOI: | 10.1080/02770903.2020.1857395 |
| Popis: | Asthma is a frequent comorbidity of bronchiectasis, with possible implications for exacerbation and severity. We investigated the clinical impact of asthma on bronchiectasis in terms of disease severity and exacerbation risk.We collected demographic, clinical, and functional characteristics of patients with a confirmed diagnosis of bronchiectasis. All patients were investigated for concomitant diagnosis of asthma. The Bhalla score was used to assess radiological severity of bronchiectasis, and the Bronchiectasis Severity Index (BSI) was used to assess the clinical severity. Blood and sputum samples were collected to assess blood cell count, erythrocyte sedimentation rate, c-reactive protein, immunological status (IgA, IgE, IgM, IgG, and IgG subclasses), and microbiological analysis.A total of 106 patients were enrolled in the study; 30.2% had concomitant asthma and were characterized by higher frequency of bronchiectasis exacerbation, despite higher Bhalla score and lower BSI compared to patients without asthma.The coexistence of asthma and bronchiectasis is associated with an independent increase in the risk of bronchiectasis exacerbation despite lower radiological and clinical severity indexes. Asthmatic airway inflammation could promote an enhanced "Cole's Cycle" that is responsible for a higher frequency of exacerbations. |
| Databáze: | OpenAIRE |
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