Bladder recovery by stem cell based cell therapy in the bladder dysfunction induced by spinal cord injury: systematic review and meta-analysis
| Autor: | Ik Sung Lim, Yun Seob Song, Young Myoung Ko, Hong Jun Lee, Byung-Wook Yoo, Jae Heon Kim, Eun Seop Song, Joyce Mary Kim, Won Jae Yang, Sung Ryul Shim, Seung Whan Doo |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Neuronal differentiation Urinary Bladder Urology lcsh:Medicine Cell therapy Medicine Animals Humans lcsh:Science Spinal cord injury Spinal Cord Injuries Multidisciplinary Urinary bladder business.industry Mesenchymal stem cell lcsh:R Stem-cell therapy Recovery of Function medicine.disease medicine.anatomical_structure Meta-analysis lcsh:Q Stem cell business Research Article Stem Cell Transplantation |
| Zdroj: | PLoS ONE, Vol 10, Iss 3, p e0113491 (2015) PLOS ONE(10): 3 PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Background Bladder dysfunction induced by spinal cord injury (SCI) can become problematic and severely impair the quality of life. Preclinical studies of spinal cord injury have largely focused on the recovery of limb function while neglecting to investigate bladder recovery. Objective The present study was performed to investigate and review the effect of stem cell-based cell therapy on bladder recovery in SCI. Methods We conducted a meta-analysis of urodynamic findings of experimental trials that included studies of stem cell-based cell therapy in SCI. Relevant studies were searched using MEDLINE, EMBASE and Cochrane Library (January 1990 -December 2012). Final inclusion was determined by a urodynamic study involving detailed numerical values. Urodynamic parameters for analysis included voiding pressure, residual urine, bladder capacity and non-voiding contraction (NVC). Meta-analysis of the data, including findings from urodynamic studies, was performed using the Mantel-Haenszel method. Results A total of eight studies were included with a sample size of 224 subjects. The studies were divided into different subgroups by different models of SCI. After a stem cell-based cell therapy, voiding pressure (-6.35, p < 0.00001, I-2 = 77%), NVC (-3.58, p < 0.00001, I-2 = 82%), residual urine (-024, p = 0.004, I-2 = 95%) showed overall significant improvement. Bladder capacity showed improvement after treatment only in the transection type (-0.23, p = 0.0002, I-2 = 0%). Conclusion After stem cell-based cell therapy in SCI, partial bladder recovery including improvement of voiding pressure, NVC, and residual urine was demonstrated. Additional studies are needed to confirm the detailed mechanism and to obtain an ideal treatment strategy for bladder recovery. |
| Databáze: | OpenAIRE |
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