Overexpression of c-Met is Associated with Poor Prognosis in Glioblastoma Multiforme: A Systematic Review and Meta-Analyses
| Autor: | Jellyca Anton, Renindra Ananda Aman, Henry Riyanto Sofyan, Eka Susanto, Endang Nuryadi, Sudibio Sudibio, Handoko Handoko, Henry Kodrat, Tiara Bunga Mayang Permata, Soehartati Gondhowiardjo, Rahmad Mulyadi |
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| Rok vydání: | 2021 |
| Předmět: |
Oncology
medicine.medical_specialty Poor prognosis C-Met Brain Neoplasms business.industry Kaplan-Meier Estimate General Medicine Proto-Oncogene Proteins c-met Prognosis medicine.disease Progression-Free Survival chemistry.chemical_compound chemistry Internal medicine Overall survival medicine Humans Immunohistochemistry Progression-free survival Glioblastoma business |
| Zdroj: | Asian Pacific Journal of Cancer Prevention. 22:3075-3080 |
| ISSN: | 2476-762X |
| DOI: | 10.31557/apjcp.2021.22.10.3075 |
| Popis: | Objective: The aim of this study is to evaluate the association of c-Met overexpression with survival of glioblastoma multiforme (GBM) patients. Methods: A systematic review with meta-analyses was conducted on related articles from PubMed, EBSCOhost, Scopus, and Cochrane databases with last updated search on October 31, 2020. A total of 7 studies regarding c-Met overexpression and overall survival (OS) and/or progression free survival (PFS) are included in this study. Results: All studies used immunohistochemistry to examine the expression of c-Met protein. The results showed that the positive rate of c-Met overexpression was detected in approximately 33,9% - 60,5% of GBM patients. c-Met overexpression was related to worse OS (HR: 1,74; 95% CI: 1,482-2,043; Z=6,756; p |
| Databáze: | OpenAIRE |
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