Gene and prognostic value of N6-methyladenosine (m6A) modification regulatory factors in lung adenocarcinoma
| Autor: | RongQiang Zhang, Yongmin Xiong, Xiaoli Yang, Dandan Zhang, Di Zhang, Chen Wang, Qiang Li |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
HNRNPC Adenosine Lung Neoplasms Epidemiology Alpha-Ketoglutarate-Dependent Dioxygenase FTO Adenocarcinoma of Lung Treatment of lung cancer chemistry.chemical_compound medicine Humans Lung cancer Cause of death Lung business.industry Public Health Environmental and Occupational Health Cancer Methyltransferases medicine.disease Prognosis medicine.anatomical_structure Oncology chemistry Cancer research Adenocarcinoma N6-Methyladenosine business |
| Zdroj: | European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)Reference. 31(4) |
| ISSN: | 1473-5709 |
| Popis: | Lung cancer is the leading cause of death worldwide, and its incidence continues to increase. The treatment of lung cancer is related to the subtypes and stages of cancer, but the therapeutic effect is still unsatisfactory. We found that 10 of the 13 genes were differentially expressed in lung cancer, YTHDF1, RBM15, HNRNPC, KIAA1429, METTL3 and YTHDF2 are high expression while METTL14, ZC3H13, FTO and WTAP are low expression. HNRNPC and METTL3 genes were associated with the risk and prognosis of LUAD and could regard as biomarkers for early diagnosis and treatment, which provides a theoretical basis for LUAD. |
| Databáze: | OpenAIRE |
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