Regional Brain Stem Atrophy in Idiopathic Parkinson's Disease Detected by Anatomical MRI
| Autor: | Clotilde Degroot, Benoit Kullmann, Oury Monchi, Thomas Jubault, Antonio P. Strafella, Anne-Louise Lafontaine, Sylvain Chouinard, Simona Maria Brambati |
|---|---|
| Přispěvatelé: | Université de Montréal. Faculté des arts et des sciences. Département de psychologie |
| Rok vydání: | 2009 |
| Předmět: |
Male
Pathology medicine.medical_specialty lcsh:Medicine Substantia nigra Brain damage Neuropathology Grey matter Biology 03 medical and health sciences 0302 clinical medicine Atrophy medicine Humans lcsh:Science Neurological Disorders/Movement Disorders 030304 developmental biology 0303 health sciences Multidisciplinary lcsh:R Radiology and Medical Imaging/Magnetic Resonance Imaging Parkinson Disease Voxel-based morphometry Middle Aged medicine.disease Magnetic Resonance Imaging Neurological Disorders/Neuroimaging Pons medicine.anatomical_structure Organ Specificity lcsh:Q Female Brainstem medicine.symptom 030217 neurology & neurosurgery Brain Stem Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 4, Iss 12, p e8247 (2009) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0008247 |
| Popis: | Idiopathic Parkinson's disease (PD) is a neurodegenerative disorder characterized by the dysfunction of dopaminergic dependent cortico-basal ganglia loops and diagnosed on the basis of motor symptoms (tremors and/or rigidity and bradykinesia). Post-mortem studies tend to show that the destruction of dopaminergic neurons in the substantia nigra constitutes an intermediate step in a broader neurodegenerative process rather than a unique feature of Parkinson's disease, as a consistent pattern of progression would exist, originating from the medulla oblongata/pontine tegmentum. To date, neuroimaging techniques have been unable to characterize the pre-symptomatic stages of PD. However, if such a regular neurodegenerative pattern were to exist, consistent damages would be found in the brain stem, even at early stages of the disease. We recruited 23 PD patients at Hoenn and Yahr stages I to II of the disease and 18 healthy controls (HC) matched for age. T1-weighted anatomical scans were acquired (MPRAGE, 1 mm3 resolution) and analyzed using an optimized VBM protocol to detect white and grey matter volume reduction without spatial a priori. When the HC group was compared to the PD group, a single cluster exhibited statistical difference (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|