The Effect of Vitamin D Supplementation on Glycemic Control and Lipid Profile in Patients with Type 2 Diabetes Mellitus
| Autor: | Magda I Mohamad, Enas E El-Sherbeny, Meram M Bekhet |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty endocrine system diseases Medicine (miscellaneous) 030209 endocrinology & metabolism 030204 cardiovascular system & hematology 03 medical and health sciences Sex Factors 0302 clinical medicine Diabetes mellitus Internal medicine Vitamin D and neurology Humans Medicine In patient Vitamin D Glycemic Glycated Hemoglobin Nutrition and Dietetics Vitamin d supplementation medicine.diagnostic_test business.industry Cholesterol HDL Type 2 Diabetes Mellitus Cholesterol LDL Fasting Middle Aged medicine.disease Lipids Cholesterol Endocrinology Diabetes Mellitus Type 2 Dietary Supplements Female lipids (amino acids peptides and proteins) Hemoglobin business Lipid profile |
| Zdroj: | Journal of the American College of Nutrition. 35:399-404 |
| ISSN: | 1541-1087 0731-5724 |
| DOI: | 10.1080/07315724.2015.1026427 |
| Popis: | The aim of this study was to evaluate the effect of vitamin D supplementation in patients with type 2 diabetes mellitus (T2DM) with regard to their glycemic control and lipid profile.One hundred subjects with T2DM were recruited and given 4500 IU/day of vitamin D for 2 months. 25-Hydroxyvitamin D [25(OH)D], fasting blood glucose (FBG), glycosylated hemoglobin A1c (HbA1c), and lipid profile were measured pre- and postsupplementation.There was a significant increase in the mean value of 25(OH)D level after supplementation (baseline level 16 ± 5.3 ng/ml vs. after supplement level 49.2 ± 17.7 ng/ml, p0.05). Both FBG and HbA1c but not lipid profile were significantly decreased after supplementation. However, the univariate general linear model between 25(OH)D percentiles and lipid profile levels showed that diabetic subjects with high 25(OH)D levels (61 ng/ml) had significantly lower levels of total cholesterol and low-density lipoprotein cholesterol (LDL-C) in comparison to those in the low or middle percentiles. Furthermore, participants in a higher percentile had a significantly higher level of high-density lipoprotein cholesterol (HDL-C) than those in the middle percentile. Lipid profile levels were not affected by the supplement except for triglycerides (TG) levels in females, which were significantly decreased.Vitamin D supplementation may be beneficial to diabetic subjects because it improved glycemic control. Diabetic subjects with high 25(OH)D levels (61 ng/ml) had better lipid profiles. |
| Databáze: | OpenAIRE |
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