Neurofeedback for Attention-Deficit/Hyperactivity Disorder: 25-Month Follow-up of Double-Blind Randomized Controlled Trial

Autor: L Eugene, Arnold, Martijn, Arns, Justin A, Barterian, Shea, Connor, Roger J, deBeus, Jill A, Hollway, Cynthia, Kerson, Howard, Lightstone, Joel F, Lubar, Keith, McBurnett, Vincent J, Monastra, Arielle, Mulligan, Kristin, Buchan-Page, Xueliang Jeff, Pan, Robert, Rice, Michelle E, Roley-Roberts, Constance A, Schrader, Yubo, Tan, Craig, Williams
Rok vydání: 2023
Předmět:
Zdroj: Journal of the American Academy of Child & Adolescent Psychiatry. 62:435-446
ISSN: 0890-8567
DOI: 10.1016/j.jaac.2022.07.862
Popis: To examine delayed effects of theta-beta ratio (TBR) neurofeedback (NF) for attention-deficit/hyperactivity disorder (ADHD) 25 months after baseline, ∼21 months after end of treatment.Children aged 7-10 with rigorously diagnosed ADHD had been randomized to 38 sessions of TBR NF (n=84) or control treatment (n=58) of identical appearance, intensity/frequency, and duration, differing only in that reinforcement for controls was based on a pre-recorded EEG of another child. Child, parent, and all site staff were blind until after 25-month assessments, with only one-fourth able to guess the control treatment correctly. Baseline assessments were repeated off medication after 25 months.Of the 142, 120 had 25-month follow-up (84.5% retention). Only 12 (6 controls) had NF after the study treatment, greatly retaining the randomization. The primary outcome, parent-rated inattention, was not significantly different between treatments despite large pre-post effect sizes (NF, d=1.63; controls, d=1.42). Most secondary measures showed the same pattern. Response rates (CGI-I≤2) were 58.6% of NF and 66% of controls (non-significant). Marginally more controls than NF recipients needed medication (57.1% vs 38.6%, p=0.059); specifically, 7.1% of NF and 4% of controls had reduced medication need while 34.3% of NF and 50% of controls needed more medication (p=0.084).Most of the large within-group improvement from the NF treatment package reported by unblinded studies and replicated in this blinded study reflects nonspecific effects, not specific effects of deliberate downtraining of EEG theta-beta power ratio. At 25-month follow-up it appears comparable to the evidence-based MTA treatments, suggesting a psychotherapeutic/behavioral effect.
Databáze: OpenAIRE