Extracorporeal Liver Ablation Using Sonography-Guided High-Intensity Focused Ultrasound
| Autor: | Jay L. Grosfeld, Carlos A. Galliani, F. J. Fry, Rong Yang, Nerandra T. Sanghvi, Steven L. Griffith, Frederick J. Rescorla |
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| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty business.industry medicine.medical_treatment Radiation beam General Medicine Ablation medicine.disease High-intensity focused ultrasound Extracorporeal Coagulative necrosis Liver medicine Rabbit model Animals Ultrasonics Radiology Nuclear Medicine and imaging Rabbits Radiology business Liver cancer Ultrasonography Tissue volume |
| Zdroj: | Investigative Radiology. 27:796-803 |
| ISSN: | 0020-9996 |
| DOI: | 10.1097/00004424-199210000-00009 |
| Popis: | RATIONALE AND OBJECTIVES High-intensity focused ultrasound (HIFU) is the only radiation beam that can remotely destroy deep-seated tissue targets without causing damage to the intervening tissues. This study evaluates the ability of sonography-guided HIFU to extracorporeally induce liver ablation in a rabbit model. METHODS Under sonographic guidance, the HIFU beam was transcutaneously focused at the target tissue in the liver through a subcostal approach. A computer controlled the HIFU exposure and transducer movement to destroy a preselected tissue volume. Simultaneous sonography monitored the tissue response. Ten insonated rabbits were killed from days 0 to 10, and the liver and intervening tissues were examined histologically. RESULTS A sharply demarcated sonolesion of coagulation necrosis was produced in the liver in 9 of 10 animals. No damage was found in the intervening tissues (n = 6) when adequate acoustic coupling and proper beam path was applied. CONCLUSION Sonography-guided HIFU might be a potential new modality for extracorporeal inducement of liver cancer ablation without resorting to laparatomy. |
| Databáze: | OpenAIRE |
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