Occupational radiation exposure and glaucoma and macular degeneration in the US radiologic technologists

Autor: Marie Odile Bernier, Jeremy S. Miller, Bruce H. Alexander, Mark P. Little, Nobuyuki Hamada, David Borrego, Cari M. Kitahara, Michele M. Doody, Martha S. Linet, Elizabeth K. Cahoon, Craig Meyer, Raquel Velazquez-Kronen, Dale L. Preston, Steven L. Simon
Přispěvatelé: Laboratoire d'épidémiologie des rayonnements ionisants (LEPID), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), University of Minnesota [Crookston], University of Minnesota System, Division of Cancer Epidemiology and Genetics, National Cancer Institute, DCEGNational Institutes of Health, NIHNational Cancer Institute, NCI
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2018, 8 (1), pp.10481. ⟨10.1038/s41598-018-28620-6⟩
ISSN: 2045-2322
DOI: 10.1038/s41598-018-28620-6
Popis: There are well-documented associations of glaucoma with high-dose radiation exposure, but only a single study suggesting risk of glaucoma, and less conclusively macular degeneration, associated with moderate-dose exposure. We assessed risk of glaucoma and macular degeneration associated with occupational eye-lens radiation dose, using participants from the US Radiologic Technologists Study, followed from the date of surveys in 1994–1998, 2003–2005 to the earliest of diagnosis of glaucoma or macular degeneration, cancer other than non-melanoma skin cancer, or date of last survey (2012–2014). We excluded those with baseline disease or previous radiotherapy history. Cox proportional hazards models with age as timescale were used. There were 1631 cases of newly self-reported doctor-diagnosed cases of glaucoma and 1331 of macular degeneration among 69,568 and 69,969 eligible subjects, respectively. Estimated mean cumulative eye-lens absorbed dose from occupational radiation exposures was 0.058 Gy. The excess relative risk/Gy for glaucoma was −0.57 (95% CI −1.46, 0.60, p = 0.304) and for macular degeneration was 0.32 (95% CI −0.32, 1.27, p = 0.381), suggesting that there is no appreciable risk for either endpoint associated with low-dose and low dose-rate radiation exposure. Since this is the first examination of glaucoma and macular degeneration associated with low-dose radiation exposure, this result needs to be replicated in other low-dose studies.
Databáze: OpenAIRE
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