Intravitreous and Plasma Concentrations of Ganciclovir and Foscarnet after Intravenous Therapy in Patients with AIDS and Cytomegalovirus Retinitis
| Autor: | Edmund V. Capparelli, James D. Connor, C Gonzalez, R F Garcia, J Gambertoglio, William R. Freeman, Germaine Bergeron-Lynn, Leonard S. Kirsch, J F Arevalo, Jose I. Quiceno |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Ganciclovir Foscarnet medicine.medical_specialty medicine.medical_treatment Retinitis Vitrectomy Gastroenterology Pharmacokinetics Internal medicine Blood plasma medicine Humans Immunology and Allergy Prospective Studies Acquired Immunodeficiency Syndrome business.industry Retinal Detachment virus diseases Retinal detachment Middle Aged medicine.disease eye diseases Surgery Vitreous Body Infectious Diseases Cytomegalovirus Retinitis Injections Intravenous Drug Therapy Combination Female Cytomegalovirus retinitis business medicine.drug |
| Zdroj: | Journal of Infectious Diseases. 172:951-956 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/172.4.951 |
| Popis: | This study evaluated intravitreous and plasma ganciclovir and foscarnet concentrations after intravenous administration in AIDS patients with cytomegalovirus (CMV) retinitis and retinal detachment. Undiluted vitreous samples were prospectively obtained from 60 eyes (52 patients) at the time of pars plana vitrectomy. Thirty-three plasma samples (from 27 patients in the initial group of 52) were obtained simultaneously during surgery on 33 eyes. High-pressure liquid chromatography showed the mean vitreous ganciclovir concentrations in patients on induction and maintenance therapy were, respectively, 4.74 +/- 1.49 microM (n = 24) and 3.29 +/- 1.84 microM (n = 30; P = .005). Simultaneous plasma ganciclovir concentrations were less than the vitreous concentrations in 78% of the patients. The mean intravitreous foscarnet concentrations in patients receiving induction dosages were 189 +/- 177 microM (n = 5) versus 163 +/- 167 microM (n = 4; P > .20) for those receiving maintenance therapy. The foscarnet vitreous plasma concentration ratio averaged 1.43. Current drugs and doses for CMV retinitis result in borderline or progressively subtherapeutic concentrations. |
| Databáze: | OpenAIRE |
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