Incorporating Magnetic Resonance Imaging (MRI) Based Radiation Therapy Response Prediction into Clinical Practice for Locally Advanced Cervical Cancer Patients
| Autor: | Sophie Espenel, Pierre Annede, Sophie Bockel, Michael Majer, Florence Huguet, Fabien Mignot, S. Achkar, A. Schernberg, Alexandre Escande, Cyrus Chargari, T. Kumar, L. Monnier |
|---|---|
| Přispěvatelé: | Service d'oncologie-radiothérapie [CHU Tenon], CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Radiothérapie Moléculaire et Innovation Thérapeutique (RaMo-IT), Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay |
| Rok vydání: | 2020 |
| Předmět: |
Cancer Research
medicine.medical_specialty Neoplasm Residual [SDV]Life Sciences [q-bio] medicine.medical_treatment Brachytherapy Locally advanced Uterine Cervical Neoplasms 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Humans Medicine Radiology Nuclear Medicine and imaging Cervical cancer medicine.diagnostic_test business.industry Radiotherapy Planning Computer-Assisted Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging Tumor Burden 3. Good health Functional imaging Clinical Practice Radiation therapy Oncology 030220 oncology & carcinogenesis Female Radiology business Chemoradiotherapy Radiotherapy Image-Guided |
| Zdroj: | Seminars in Radiation Oncology Seminars in Radiation Oncology, WB Saunders, 2020, 30, pp.291-299. ⟨10.1016/j.semradonc.2020.05.007⟩ |
| ISSN: | 1053-4296 |
| DOI: | 10.1016/j.semradonc.2020.05.007 |
| Popis: | In recent years, magnetic resonance imaging (MRI) has become one of the standard imaging tools to define the macroscopic gross tumor volume in locally advanced cervical cancer patients based on T2-weighted sequence. Recent data suggest that functional MRI could be used to potentially improve the delineation of target volumes based on physiologic features, defining radioresistant subvolumes that may require higher doses to achieve local cure. Functional imaging can be used to predict tumor biology and outcome, as well as for assessment of tumor response during radiotherapy. The concept of adaptive radiotherapy relies on the possibility of monitoring variations in target volumes structures to guide treatment-plan modification during radiotherapy, taking into account not only internal movements but also tumor response. With integrated MRI in radiotherapy linear accelerators, motion monitoring during treatment delivery has become available. MRI can be also used to accurately evaluate cervical tumor residual volume after chemoradiotherapy, and therefore allowing a personalized treatment planning for brachytherapy boost, based on tumor radiosensitivity. In this review, we discuss how MRI tumor response assessment could be included into clinical practice during radiation therapy in locally advanced cervical cancer patients. |
| Databáze: | OpenAIRE |
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