Involvement of the serotonergic system in the anxiolytic-like effect of 2-phenylethynyl butyltellurium in mice
| Autor: | Tuane Bazanella Sampaio, Juliana T. da Rocha, Cristina W. Nogueira, Gilson Zeni, Caroline B. Quines, José S. S. Neto, Ana Paula Pesarico |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
Serotonin medicine.medical_specialty Monoamine oxidase Anxiety Serotonergic Mice Behavioral Neuroscience Internal medicine Monoaminergic Organometallic Compounds medicine Animals Monoamine Oxidase Behavior Animal biology Disease Models Animal medicine.anatomical_structure Endocrinology Anti-Anxiety Agents Mechanism of action Cerebral cortex biology.protein medicine.symptom Monoamine oxidase A Psychology |
| Zdroj: | Behavioural Brain Research. 277:221-227 |
| ISSN: | 0166-4328 |
| Popis: | Anxiety is a serious disorder with symptoms manifested at the psychological, behavioral, and physiological levels, accompanied by alterations in the serotonergic system and monoaminergic signaling. In this study, the anxiolytic-like effect of 2-phenylethynyl butyltellurium (PEBT), in three well-consolidated anxiety mouse models (light-dark test, novelty suppressed-feeding, elevated plus-maze), was investigated. The involvement of the serotonergic system, synaptosomal [(3)H] serotonin (5-HT) uptake and monoamine oxidase (MAO A and B) activities on cerebral cortices of mice, was examined. Mice received PEBT (1mg/kg, by intragastric route, i.g.) or canola oil (10 ml/kg, i.g.) 30 min before behavioral tests. The results showed that PEBT was effective in increasing the time spent by mice in the illuminated side on the light-dark box and in the open arms on the elevated plus-maze. PEBT decreased the latency to begin eating on the novelty suppressed-feeding test, indicating an anxiolytic-like effect of PEBT. Furthermore, PEBT reduced [(3)H] 5-HT uptake and selectively inhibited MAO-A activity in cerebral cortex, suggesting the involvement of the serotonergic system in the mechanism of action of this tellurium compound. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect