Alterations in amino acid status in cats with feline dysautonomia
| Autor: | Herb W. Symonds, J.A. Turner, Joanna Stratton, C. M. Knottenbelt, Susan MacDonald, Tom A. Cave, R. Scott Pirie, Bruce McGorum, Irene Leon |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male lcsh:Medicine Cat Diseases Biochemistry 0403 veterinary science chemistry.chemical_compound Methionine Medicine and Health Sciences Ingestion Amino Acids lcsh:Science chemistry.chemical_classification Mammals Multidisciplinary CATS Organic Compounds Neurochemistry 04 agricultural and veterinary sciences Neurotransmitters Amino acid Chemistry Vertebrates Physical Sciences Amino Acid Analysis Female Glutamate Research Article medicine.medical_specialty 040301 veterinary sciences Equines Cystine Primary Dysautonomias Biology Research and Analysis Methods 03 medical and health sciences Internal medicine medicine sulphur amino acids Animals Sulfur Containing Amino Acids Grass sickness Horses Cysteine Molecular Biology Techniques Molecular Biology Nutrition methionine amino acids Molecular Biology Assays and Analysis Techniques 030109 nutrition & dietetics lcsh:R Organic Chemistry Feline dysautonomia Organisms Chemical Compounds Biology and Life Sciences Proteins Diet Endocrinology chemistry Food Amniotes Cats lcsh:Q Xenobiotic Neuroscience |
| Zdroj: | PLoS ONE PLoS ONE, Vol 12, Iss 3, p e0174346 (2017) McGorum, B, Symonds, H W, Knottenbelt, C, Cave, T A, MacDonald, S J, Stratton, J, Leon, I, Turner, J A & Pirie, R 2017, ' Alterations in amino acid status in cats with feline dysautonomia ', PLoS ONE, vol. 12, no. 3, e0174346 . https://doi.org/10.1371/journal.pone.0174346 |
| ISSN: | 1932-6203 |
| Popis: | Feline dysautonomia (FD) is a multiple system neuropathy of unknown aetiology. An apparently identical disease occurs in horses (equine grass sickness, EGS), dogs, rabbits, hares, sheep, alpacas and llamas. Horses with acute EGS have a marked reduction in plasma concentrations of the sulphur amino acids (SAA) cyst(e)ine and methionine, which may reflect exposure to a neurotoxic xenobiotic. The aim of this study was to determine whether FD cats have alterations in amino acid profiles similar to those of EGS horses. Amino acids were quantified in plasma/serum from 14 FD cats, 5 healthy in-contact cats which shared housing and diet with the FD cats, and 6 healthy control cats which were housed separately from FD cats and which received a different diet. The adequacy of amino acids in the cats’ diet was assessed by determining the amino acid content of tinned and dry pelleted foods collected immediately after occurrences of FD. Compared with controls, FD cats had increased concentrations of many essential amino acids, with the exception of methionine which was significantly reduced, and reductions in most non-essential amino acids. In-contact cats also had inadequate methionine status. Artefactual loss of cysteine during analysis precluded assessment of the cyst(e)ine status. Food analysis indicated that the low methionine status was unlikely to be attributable to dietary inadequacy of methionine or cystine. Multi-mycotoxin screening identified low concentrations of several mycotoxins in dry food from all 3 premises. While this indicates fungal contamination of the food, none of these mycotoxins appears to induce the specific clinico-pathologic features which characterise FD and equivalent multiple system neuropathies in other species. Instead, we hypothesise that ingestion of another, as yet unidentified, dietary neurotoxic mycotoxin or xenobiotic, may cause both the characteristic disease pathology and the plasma SAA depletion. |
| Databáze: | OpenAIRE |
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