Early effects triggered by Larrea divaricata Cav. on murine macrophages at apoptotic concentrations

Autor:	Yolanda Casali, Carina Porporatto, Aida Mattar, Silvia G. Correa, Blas Micalizzi, Roberto Davicino
Rok vydání:	2007
Předmět:	Lipopolysaccharides Male Phagocytosis Immunology Acid Phosphatase Lipopolysaccharide Receptors Decoction Apoptosis Pharmacology Biology In Vitro Techniques Toxicology Nitric Oxide Antioxidants Nitric oxide chemistry.chemical_compound Mice Immunology and Allergy Animals Masoprocol Limulus Test Larrea divaricata Respiratory Burst Plant Extracts Tumor Necrosis Factor-alpha Macrophages Zymosan General Medicine Flow Cytometry Larrea Nordihydroguaiaretic acid Plant Leaves chemistry Female Cell activation
Zdroj:	Immunopharmacology and immunotoxicology. 29(3-4)
ISSN:	0892-3973
Popis:	Decoction and infusion of Larrea divaricata were tested at apoptotic concentrations (1 and 4 mg/ml) on peritoneal murine macrophages. Consistent changes were observed after incubation with 4 mg/ml decoction. Phagocytosis of zymosan, lysosomal enzyme activity, nitric oxide production, TNF-alpha release, and expression of CD14, TLR4, and CR3 increased significantly. Decoction at 1 and 4 mg/ml increased the binding of LPS-FITC. Apoptosis triggered by L. divaricata decoction is consequence of cell activation. The effects are independent of nordihydroguaiaretic acid. This "activation and death" could be the mechanism of L. divaricata to exert the antituberculosis effect known in folk medicine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27e975435954fb17ce7438b8bd9bf7b6 https://pubmed.ncbi.nlm.nih.gov/18075869 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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