Adipose Tissue-Derived Stem Cells in Regenerative Medicine
Autor: | S Simon Hoerstrup, Petra E. Dijkman, Laura Frese |
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Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Clinical uses of mesenchymal stem cells Review Article Biology Regenerative medicine Cell therapy 03 medical and health sciences SDG 3 - Good Health and Well-being Tissue engineering Therapeutic application medicine Immunology and Allergy Adipose tissue-derived stem cells Stem cell transplantation for articular cartilage repair Mesenchymal stem cell Hematology Cell biology 030104 developmental biology Multipotent Stem Cell Mesenchymal stem cells Stem cell Adult stem cell |
Zdroj: | Transfusion Medicine and Hemotherapy. 43:268-274 |
ISSN: | 1660-3818 1660-3796 |
Popis: | In regenerative medicine, adult stem cells are the most promising cell types for cell-based therapies. As a new source for multipotent stem cells, human adipose tissue has been introduced. These so called adipose tissue-derived stem cells (ADSCs) are considered to be ideal for application in regenerative therapies. Their main advantage over mesenchymal stem cells derived from other sources, e.g. from bone marrow, is that they can be easily and repeatable harvested using minimally invasive techniques with low morbidity. ADSCs are multipotent and can differentiate into various cell types of the tri-germ lineages, including e.g. osteocytes, adipocytes, neural cells, vascular endothelial cells, cardiomyocytes, pancreatic β-cells, and hepatocytes. Interestingly, ADSCs are characterized by immunosuppressive properties and low immunogenicity. Their secretion of trophic factors enforces the therapeutic and regenerative outcome in a wide range of applications. Taken together, these particular attributes of ADSCs make them highly relevant for clinical applications. Consequently, the therapeutic potential of ADSCs is enormous. Therefore, this review will provide a brief overview of the possible therapeutic applications of ADSCs with regard to their differentiation potential into the tri-germ lineages. Moreover, the relevant advancements made in the field, regulatory aspects as well as other challenges and obstacles will be highlighted. |
Databáze: | OpenAIRE |
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