Role of vitamin D supplements in prevention of hungry bone syndrome after successful parathyroidectomy for primary hyperparathyroidism: A prospective study
| Autor: | Ahmed F.A. Youssef, Tarek Ftohy, Ahmed Abdallah Salman, Karim K. Maurice, Mohamed Abdalla Salman, Hossam El-Din Shaaban, Hany A Balamoun, Ahmed Rabiee |
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| Rok vydání: | 2020 |
| Předmět: |
Parathyroidectomy
Pediatrics medicine.medical_specialty business.industry medicine.medical_treatment Incidence (epidemiology) 030209 endocrinology & metabolism Hyperparathyroidism Primary medicine.disease 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Dietary Supplements Vitamin D supplement medicine Vitamin D and neurology Humans Surgery Prospective Studies Vitamin D business Prospective cohort study Primary hyperparathyroidism |
| Zdroj: | Scandinavian Journal of Surgery. 110:329-334 |
| ISSN: | 1799-7267 1457-4969 |
| DOI: | 10.1177/1457496920962601 |
| Popis: | Background: We postulated that the preoperative correction of vitamin D levels can significantly reduce the incidence of hunger bone syndrome among patients undergoing parathyroidectomy for primary hyperparathyroidism. Methods: We performed a prospective, randomized, open-label study on 102 patients with primary hyperparathyroidism and coexisting vitamin D deficiency who were scheduled to undergo parathyroidectomy. Patients were divided into the following two groups: group I which included 52 patients who did not receive preoperative vitamin D supplementation; and group II which included 50 patients who received cholecalciferol 1000–2000 IU daily or 50000 IU weekly until they achieve vitamin D levels >20 ng/mL (group IIa = 25 patients) or vitamin D levels >30 ng/mL (group IIb = 25 patients). Results: The incidence of hunger bone syndrome in group IIb was lower than group I and group IIa (8% versus 16% versus 23%, respectively); however, this difference did not reach the level of statistical significance (p = 0.22). Patients with hunger bone syndrome were significantly younger and had higher serum phosphorus, alkaline phosphatase, magnesium, and bone mineral density at baseline than patients without hunger bone syndrome. On the other hand, patients with hunger bone syndrome had significantly lower 25-hydroxyvitamin D at baseline than patients without hunger bone syndrome (p = 0.001). The ROC curve showed that the baseline level of serum 25-hydroxyvitamin D was not an independent discriminator of hunger bone syndrome (area under curve = 0.21 (95% CI: 0.06–0.34); p = 0.011). Conclusions: Preoperative course of vitamin D supplements has no preventive role on the postoperative incidence of hunger bone syndrome among patients with primary hyperparathyroidism and coexisting vitamin D deficiency undergoing parathyroidectomy. |
| Databáze: | OpenAIRE |
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