The immunoenhancement effects of sea buckthorn pulp oil in cyclophosphamide-induced immunosuppressed mice
| Autor: | Xiu-Fang Zhang, Hong-Chang Zhou, Xiao-Yu Li, Hui Zhang, Shuai-Bing He, Yu-Hang Ling, Dian-Dong Hou, Jin Zhang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Spleen Gut flora Microbiology law.invention 03 medical and health sciences Probiotic Immunocompromised Host Immunomodulating Agents Mice 0302 clinical medicine Immune system stomatognathic system Intestinal mucosa law Lactobacillus Hippophae medicine Mesenteric lymph nodes Animals Humans Plant Oils Intestinal Mucosa Cyclophosphamide Inflammation Mice Inbred BALB C biology Chemistry General Medicine biology.organism_classification Gastrointestinal Microbiome 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Pulp (tooth) Female Immunosuppressive Agents Food Science |
| Zdroj: | Foodfunction. 12(17) |
| ISSN: | 2042-650X |
| Popis: | In this study, the immunomodulatory effect of sea buckthorn (SBT) pulp oil was elucidated in immunosuppressed Balb/c mice induced by cyclophosphamide (CTX). The results showed that SBT pulp oil could reverse the decreasing trend of body weight, thymus/spleen index and hematological parameters induced by CTX. Compared with immunosuppressive mice induced by CTX, SBT pulp oil could enhance NK cytotoxicity, macrophage phagocytosis, and T lymphocyte proliferation, and regulate the proportion of T cell subsets in mesenteric lymph nodes (MLN), and promote the production of secretory immunoglobulin A (sIgA), IFN-γ, IL-2, IL-4, IL-12 and TNF-α in the intestines. In addition, SBT pulp oil can promote the production of short fatty acids (SCFAs), increase the diversity of gut microbiota, improve the composition of intestinal flora, increase the abundance of Alistipes, Bacteroides, Anaerotruncus, Lactobacillus, ASF356, and Roseburia, while decreasing the abundance of Mucispirillum, Anaeroplasma, Pelagibacterium, Brevundimonas, Ochrobactrum, Acinetobacter, Ruminiclostridium, Blautia, Ruminiclostridium, Oscillibacter, and Faecalibaculum. This study shows that SBT pulp oil can regulate the diversity and composition of intestinal microflora in CTX-induced immunosuppressive Balb/c mice, thus enhancing the intestinal mucosa and systemic immune response. The results can provide a basis for understanding the function of SBT pulp oil and its application as a new probiotic and immunomodulator. |
| Databáze: | OpenAIRE |
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