Effects of Drugs and Fatty Acids Related to Reye Syndrome on Brain Water Content in Rats
| Autor: | Fumio Yamashita, Ichiro Yoshida, Yukihiko Katafuchi, Daven Sinniah |
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| Rok vydání: | 1989 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Intraperitoneal injection Body water chemistry.chemical_compound Body Water Internal medicine medicine Animals Reye Syndrome Linolenate chemistry.chemical_classification Valproic Acid business.industry Fatty Acids Brain Rats Inbred Strains Rats Disease Models Animal Endocrinology chemistry Pediatrics Perinatology and Child Health business Salicylic acid medicine.drug Polyunsaturated fatty acid Hormone |
| Zdroj: | Pediatrics International. 31:115-119 |
| ISSN: | 1442-200X 1328-8067 |
| DOI: | 10.1111/j.1442-200x.1989.tb01276.x |
| Popis: | Brain water content was measured by gas-chromatography in rats following intraperitoneal injection of drugs and fatty acids related to the etiology of Reye syndrome. A statistically significant increase in brain water content was observed following injection of 5% glucose solution, valproic acid, acetyl salicylic acid, calcium hopantenate, margosa oil, 4-pentenoic acid, linolenate and arachidonate. Seizures occurred in all animals given valproic acid, margosa oil and 4-pentenoic acid, and in 25% of those given 5% glucose solution + anti-diuretic hormone. The results of these studies may help in the selection of appropriate agents for experimental induction of acute encephalopathy and brain edema in animal models of Reye syndrome. |
| Databáze: | OpenAIRE |
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