Neurosteroid Actions in Memory and Neurologic/Neuropsychiatric Disorders
Autor: | Vidhya Kumaresan, David H. Farb, Marcia H. Ratner |
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Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Neuroactive steroid Memory Dysfunction Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Review lcsh:Diseases of the endocrine glands. Clinical endocrinology memory 03 medical and health sciences chemistry.chemical_compound Endocrinology 0302 clinical medicine medicine Biological neural network lcsh:RC648-665 Allopregnanolone Glutamate receptor allopregnanolone Alzheimer's disease anxiety medicine.disease schizophrenia 030104 developmental biology chemistry Schizophrenia depression Connectome neurosteroid pregnenolone sulfate Pregnenolone sulfate Psychology Neuroscience |
Zdroj: | Frontiers in Endocrinology, Vol 10 (2019) Frontiers in Endocrinology |
ISSN: | 1664-2392 |
Popis: | Memory dysfunction is a symptomatic feature of many neurologic and neuropsychiatric disorders; however, the basic underlying mechanisms of memory and altered states of circuitry function associated with disorders of memory remain a vast unexplored territory. The initial discovery of endogenous neurosteroids triggered a quest to elucidate their role as neuromodulators in normal and diseased brain function. In this review, based on the perspective of our own research, the advances leading to the discovery of positive and negative neurosteroid allosteric modulators of GABA type-A (GABAA), NMDA, and non-NMDA type glutamate receptors are brought together in a historical and conceptual framework. We extend the analysis toward a state-of-the art view of how neurosteroid modulation of neural circuitry function may affect memory and memory deficits. By aggregating the results from multiple laboratories using both animal models for disease and human clinical research on neuropsychiatric and age-related neurodegenerative disorders, elements of a circuitry level view begins to emerge. Lastly, the effects of both endogenously active and exogenously administered neurosteroids on neural networks across the life span of women and men point to a possible underlying pharmacological connectome by which these neuromodulators might act to modulate memory across diverse altered states of mind. |
Databáze: | OpenAIRE |
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