| Autor: |
Muhammad Furqan Akhtar, Mehr-un- Nisa, Ammara Saleem, Irfan Hamid, Khalaf F. Alsharif, Mohamed M. Abdel-Daim, Md. Habibur Rahman, Muddaser Shah, Kashif Sohail, Zeeshan Javaid |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Cellular and molecular biology (Noisy-le-Grand, France). 67(5) |
| ISSN: |
1165-158X |
| Popis: |
Fenbfen is used for pain, pyrexia and in the management of osteoarthritis, rheumatoid arthritis and other musculoskeletal disorders. The present research was planned to examine the immunomodulatory activity of fenbufen in different models of cell-mediated immunity (CMI) and humoral immunity (HI). The CMI was evaluated by delayed-type hypersensitivity (DTH) and cyclophosphamide-induced neutropenia assays while HI was appraised by hemagglutination (HA) assay by administering fenbufen at 2, 6 and 10 mg.kg-1 and azathioprine 40 mg.kg-1 (as standard therapy) to albino mice by intraperitoneal route. The ex vivo immunomodulatory action was determined by red blood cell (RBC) membrane stabilization and protein denaturation assays. The results showed that fenbufen treatment had significantly (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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