Involvement of MyoD and PEA3 in regulation of transcription activity of MDR1 gene
| Autor: | Qi Hong, Chen Yang, Kuaile Zhao, Wei Jin, Ying Chen, Li Chen, Yaxin Zhao, Jiefan Liu, Qiaoqiao Wang |
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| Rok vydání: | 2010 |
| Předmět: |
Transcriptional Activation
ATP Binding Cassette Transporter Subfamily B Biophysics Antineoplastic Agents MyoD physiological processes Biochemistry Transcription (biology) Stomach Neoplasms Cell Line Tumor polycyclic compounds Cytotoxic T cell Humans ATP Binding Cassette Transporter Subfamily B Member 1 neoplasms P-glycoprotein MyoD Protein Regulation of gene expression Gene knockdown biology PITX2 General Medicine musculoskeletal system Molecular biology body regions Gene Expression Regulation Neoplastic Drug Resistance Neoplasm Cancer cell Cancer research biology.protein Genes MDR Transcription Factors |
| Zdroj: | Acta biochimica et biophysica Sinica. 42(12) |
| ISSN: | 1745-7270 |
| Popis: | Overexpression of multidrug resistance 1 (MDR1) in cancer remains one of the major causes for the failure of chemotherapy. In the present study, we found that MyoD and PEA3 could activate P-glycoprotein (P-gp) expression in SGC7901 cells. Knockdown of MyoD and PEA3 attenuated MDR1 expression and increased the sensitivity of multidrug resistant cancer cells to cytotoxic drugs that were transported by P-gp in SGC7901/VCR cells. MyoD or PEA3 could bind to the E-box and PEA3 sites on the MDR1 promoter and activate its transcription. The regulation of MDR1 expression by MyoD and PEA3 may provide potential ways to overcome MDR in cancer treatment. |
| Databáze: | OpenAIRE |
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