Reproducibility of Fixed-luminance and Multi-luminance Flicker Electroretinography in Patients With Diabetic Retinopathy Using an Office-based Testing Paradigm
| Autor: | Alberto Gonzalez, John J Wroblewski, Kassandra Pickel, Hunter Buterbaugh, Christa McChancy, Tyler Wieland |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Biomedical Engineering Bioengineering Severity of Illness Index Luminance Retina 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Ophthalmology Electroretinography Internal Medicine medicine Humans In patient Fluorescein Angiography Aged 030304 developmental biology 0303 health sciences Office based Reproducibility Diabetic Retinopathy business.industry Reproducibility of Results Diagnostic test Original Articles Diabetic retinopathy Middle Aged medicine.disease eye diseases Flicker electroretinography 030221 ophthalmology & optometry Female business Erg |
| Zdroj: | J Diabetes Sci Technol |
| ISSN: | 1932-2968 |
| DOI: | 10.1177/1932296819882719 |
| Popis: | Background: We evaluated the reproducibility of office-based flicker electroretinography (ERG) in patients with nonproliferative diabetic retinopathy (NPDR). Methods: An observational study was conducted in which ultra-widefield fluorescein angiography (UWF-FA) was performed on 20 patients with mild-to-moderate NPDR; images were graded by the Fundus Photography Reading Center (Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI, USA). Fixed- and multi-luminance flicker ERG was repeated four times (greater than or equal to seven days apart). Recording consistency was assessed using intra-class correlation coefficients (ICCs), coefficients of variation, and Pearson correlations. Results: 82.5% and 17.5% of eyes had mild and moderate NPDR using UWF-FA; 90% of the angiograms were given a high confidence grade. Fixed-luminance phase values were highly reproducible (ICC: 0.949; P Conclusions: Office-based, fixed-luminance phase values are highly reproducible and negatively correlate with retinal ischemia in NPDR, suggesting that global retinal dysfunction may be reliably quantified early in patients with diabetes. |
| Databáze: | OpenAIRE |
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