Calibration of thresholds for functional engagement of vagal A, B and C fiber groups in vivo
| Autor: | John B. Furness, David Trevaks, A.D. Shafton, Robin M. McAllen, Bradford Bratton |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Bradycardia Hering–Breuer reflex medicine.medical_specialty Respiratory rate business.industry digestive oral and skin physiology Stimulation General Medicine Stimulus (physiology) Vagus nerve 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Internal medicine Heart rate medicine Cardiology medicine.symptom Respiratory system business 030217 neurology & neurosurgery Research Article |
| Zdroj: | Bioelectronics in Medicine. 1:21-27 |
| ISSN: | 2059-1519 2059-1500 |
| DOI: | 10.2217/bem-2017-0001 |
| Popis: | Vagal nerve stimulation is widely used therapeutically but the fiber groups activated are often unknown. Aim: To establish a simple protocol to define stimulus thresholds for vagal A, B and C fibers. Methods: The intact left or right cervical vagus was stimulated with 0.1 ms pulses in spontaneously breathing anesthetized rats. Heart and respiratory rate responses to vagal stimulation were recorded. The vagus was subsequently cut distally, and mass action potentials to the same stimuli were recorded. Results: Stimulating at either 50 Hz for 2 s or 2 Hz for 10 s at experimentally determined strengths revealed A, B and C fiber thresholds that were related to respiratory and heart rate changes. Conclusion: Our simple protocol discriminates vagal A, B and C fiber thresholds in vivo. |
| Databáze: | OpenAIRE |
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