The safety assessment of saffron (Crocus sativus L.) on sympathovagal balance and heart rate variability; a comparison with amiodarone
| Autor: | Siyavash Joukar, Mohammad-Moein Dehesh |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Sympathetic Nervous System Dose medicine.drug_class medicine.medical_treatment ved/biology.organism_classification_rank.species Amiodarone 030209 endocrinology & metabolism Pharmacology Anxiolytic 03 medical and health sciences 0302 clinical medicine Heart Rate Internal medicine Heart rate Crocus sativus Medicine Heart rate variability Animals Rats Wistar business.industry ved/biology Heart Vagus Nerve Crocus Rats Autonomic nervous system Endocrinology Anticonvulsant 030220 oncology & carcinogenesis Safety business medicine.drug |
| Zdroj: | Autonomicautacoid pharmacology. 35(4) |
| ISSN: | 1474-8673 |
| Popis: | Summary Dry stigmas of the Crocus sativus L. (Saffron) are well known in world as a popular flavouring and therapeutic agent. The anxiolytic, antidepressant, anticonvulsant and antiarrhythmic effects of saffron suggest that it may affect the autonomic control of the heart. This study assessed its safety on cardiac sympathovagal balance and heart rate variability in rat. Experimental groups were control, Saf50, Saf100, Saf200 (received saffron at dosages of 50 and 100 and 200 mg/kg/d, orally, respectively) and Amio (received 30 mg/mL/kg/d of amiodarone, orally, for 7 days) groups. On day 8, the frequency domain and time domain indices of animals' electrocardiograms were calculated. The heart rate decreased and RR interval increased in Saf200 and Amio groups (P |
| Databáze: | OpenAIRE |
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