Green carbon-based nanocomposite biomaterials through the lens of microscopes
| Autor: | Maryam Jouyandeh, Sepideh Ahmadi, Navid Rabiee, Mojtaba Bagherzadeh, Mohammad Reza Saeb, Mohammad Rabiee, Henri Vahabi |
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| Přispěvatelé: | Laboratoire Matériaux Optiques, Photonique et Systèmes (LMOPS), CentraleSupélec-Université de Lorraine (UL) |
| Rok vydání: | 2021 |
| Předmět: |
Nanostructure
Materials science Composite number 02 engineering and technology Carbon nanotube 010402 general chemistry 01 natural sciences law.invention Biomaterials symbols.namesake law Waste Management and Disposal ComputingMilieux_MISCELLANEOUS chemistry.chemical_classification Nanocomposite Renewable Energy Sustainability and the Environment Graphene Biomolecule [CHIM.MATE]Chemical Sciences/Material chemistry 021001 nanoscience & nanotechnology 0104 chemical sciences [CHIM.POLY]Chemical Sciences/Polymers chemistry Chemical engineering Drug delivery Ceramics and Composites symbols van der Waals force 0210 nano-technology |
| Zdroj: | Emergent Materials Emergent Materials, 2021, ⟨10.1007/s42247-021-00277-4⟩ |
| ISSN: | 2522-574X 2522-5731 |
| DOI: | 10.1007/s42247-021-00277-4 |
| Popis: | In this work, a green synthesis method was designed and practiced to develop bioactive and biocompatible carbon-based nanocomposites biomaterials. ZnO nanoparticles were synthesized in assistance of leaf extracts and added to a composite nanostructure composed of the reduced graphene oxide (rGO) and multi-walled carbon nanotubes (MWCNT). The resulting green nanocomposite revealed ability to make π-π interactions, hydrogen bonding, and van der Waals interactions with the doxorubicin (DOX). Then, the surface morphology of the synthesized nanocomposite was investigated, and the interrelationship between the surface morphology, relative cell viability, and drug uptake and release behavior were discussed. This phenomenon was conceptualized to optimize the interactions between the biomolecules and the substrate by reaching significant drug payload and cellular internalizations. The results suggest that the drug-nanocomposite interactions (hydrogen bonding, van der Waals, n → σ* interactions) are of prime importance which determine the ability of the developed nanocomposite to drug uptake. The porosity, encapsulation, and trapping the drug via only physical and spatial entrapment techniques are also important. |
| Databáze: | OpenAIRE |
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