Evidence for cochlear synaptopathy uncorrelated with speech-in-noise intelligibility and auditory temporal processing deficits in humans
| Autor: | Lopez-Poveda, Enrique, Johannesen, Peter T., Buzo, Byanka Cagnacci |
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| Přispěvatelé: | Universidad de Salamanca |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Forum Acusticum Forum Acusticum, Dec 2020, Lyon, France. pp.627-627, ⟨10.48465/fa.2020.0077⟩ |
| ISSN: | 2015-6537 |
| DOI: | 10.48465/fa.2020.0077⟩ |
| Popis: | International audience; Cochlear synaptopathy (or the loss of primary auditory synapses) remains a subclinical condition of uncertain prevalence. Here, we investigate whether it affects humans and whether it contributes to deficits in suprathreshold speech-in-noise intelligibility or auditory temporal processing ability. For 94 normal-hearing listeners (aged 12-68 years; 64 women), we measured click-evoked auditory brainstem responses (ABRs), self-reported lifetime noise exposure, and speech reception thresholds (SRTs) for sentences and words in stationary and fluctuating maskers. Temporal processing ability was assessed by measuring the slope of threshold-duration functions (TDSs), gap detection thresholds (GDTs) and frequency modulation detection thresholds (FMDTs). TDSs were inferred from absolute detection thresholds for brief (2-20 ms) pure tones and were corrected for the effects of long tone (500 ms) thresholds. GDTs were measured as the shortest detectable silent gap between two marker tones (2 kHz, 80 dB SPL). FMDTs were measured for a carrier tone at 1.5 kHz modulated at 2 Hz. Based on animal research, we assumed that the shallower the growth of ABR wave-I amplitude-level function (in units of μV/dB), the higher the risk of suffering from synaptopathy. We found shallower wave-I growth with increasing age but not with increasing noise exposure. SRTs in noise, TDSs and FMDT were not correlated with wave-I growth rates nor were GDTs when adjusted for the effect of absolute threshold. TDSs, GDTs and FMTDs were not correlated with noise exposure. Altogether, the data are consistent with age-related but not noise-induced synaptopathy. In addition, the data dispute the notion that synaptopathy impairs the intelligibility of supra-threshold speech in noise or the detection of gaps, frequency modulation and brief sounds. [Work supported by the Oticon Foundation (ref. 15-3571), Junta de Castilla y Leon (SAP023P17), MINECO (BFU2015-65376-P), and the European Regional Development Fund]. |
| Databáze: | OpenAIRE |
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