Neurotoxicity of Synthetic Cannabinoids JWH-081 and JWH-210
| Autor: | Young-Hoon Kim, Yeon Hee Seong, Ho Sang Jeong, Jaesuk Yun, Hoil Kang, Hyoung Soo Kim, Jisoon Shin, Hye Jin Cha, Min Ji Song, Kyoungmoon Han |
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| Rok vydání: | 2015 |
| Předmět: |
Pathology
medicine.medical_specialty Cell Poison control Histopathology Nucleus accumbens Pharmacology Biochemistry chemistry.chemical_compound Drug Discovery Synthetic cannabinoids medicine Neurotoxicity Motor function business.industry medicine.disease medicine.anatomical_structure chemistry JWH-210 Toxicity Molecular Medicine Original Article business Nucleus Synthetic cannabinoid Functional observation battery medicine.drug |
| Zdroj: | Biomolecules & Therapeutics |
| ISSN: | 1976-9148 |
| Popis: | Synthetic cannabinoids JWH-018 and JWH-250 in ‘herbal incense’ also called ‘spice’ were first introduced in many countries. Numerous synthetic cannabinoids with similar chemical structures emerged simultaneously and suddenly. Currently there are not sufficient data on their adverse effects including neurotoxicity. There are only anecdotal reports that suggest their toxicity. In the present study, we evaluated the neurotoxicity of two synthetic cannabinoids (JWH-081 and JWH-210) through observation of various behavioral changes and analysis of histopathological changes using experimental mice with various doses (0.1, 1, 5 mg/kg). In functional observation battery (FOB) test, animals treated with 5 mg/kg of JWH-081 or JWH-210 showed traction and tremor. Their locomotor activities and rotarod retention time were significantly (p |
| Databáze: | OpenAIRE |
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