Dihydroartemisinin as a Putative STAT3 Inhibitor, Suppresses the Growth of Head and Neck Squamous Cell Carcinoma by Targeting Jak2/STAT3 Signaling

Autor: Lihong Pi, Xiuying Lu, Qi Song, Lifeng Jia, Yupeng Shen, Chenyang Zhou, Xiaoming Li, Xiuru Ma, Hui Li
Rok vydání: 2016
Předmět:
Male
STAT3 Transcription Factor
0301 basic medicine
genetic structures
medicine.medical_treatment
Blotting
Western
lcsh:Medicine
Dihydroartemisinin
Apoptosis
Biology
Mice
03 medical and health sciences
0302 clinical medicine
In vivo
Tumor Cells
Cultured
medicine
Animals
Humans
Phosphorylation
lcsh:Science
Cell Proliferation
Cisplatin
Mice
Inbred BALB C
Wound Healing
Multidisciplinary
Cell growth
lcsh:R
food and beverages
Cell migration
Janus Kinase 2
Flow Cytometry
medicine.disease
Xenograft Model Antitumor Assays
Head and neck squamous-cell carcinoma
Artemisinins
stomatognathic diseases
030104 developmental biology
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Carcinoma
Squamous Cell
Cancer research
lcsh:Q
lipids (amino acids
peptides
and proteins)
Signal transduction
Research Article
Signal Transduction
medicine.drug
Zdroj: PLoS ONE, Vol 11, Iss 1, p e0147157 (2016)
PLoS ONE
ISSN: 1932-6203
Popis: Developing drugs that can effectively block STAT3 activation may serve as one of the most promising strategy for cancer treatment. Currently, there is no putative STAT3 inhibitor that can be safely and effectively used in clinic. In the present study, we investigated the potential of dihydroartemisinin (DHA) as a putative STAT3 inhibitor and its antitumor activities in head and neck squamous cell carcinoma (HNSCC). The inhibitory effects of DHA on STAT3 activation along with its underlying mechanisms were studied in HNSCC cells. The antitumor effects of DHA against HNSCC cells were explored both in vitro and in vivo. An investigation on cooperative effects of DHA with cisplatin in killing HNSCC cells was also implemented. DHA exhibited remarkable and specific inhibitory effects on STAT3 activation via selectively blocking Jak2/STAT3 signaling. Besides, DHA significantly inhibited HNSCC growth both in vitro and in vivo possibly through induction of apoptosis and attenuation of cell migration. DHA also synergized with cisplatin in tumor inhibition in HNSCC cells. Our findings demonstrate that DHA is a putative STAT3 inhibitor that may represent a new and effective drug for cancer treatment and therapeutic sensitization in HNSCC patients.
Databáze: OpenAIRE
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