HIV/HBV coinfection: temporal trends and patient characteristics, Spain, 2002 to 2018
Autor: | Pérez-Latorre, Leire, Berenguer, Juan, Micán, Rafael, Montero, Marta, Cifuentes, Carmen, Puig, Teresa, Sanz, José, Ferrero, Oscar L, De La Fuente, Belén, Rodríguez, Carmen, Reus, Sergio, Hernández-Quero, José, Gaspar, Gabriel, Pérez-Martínez, Laura, García, Coral, Force, Luis, Veloso, Sergio, De Miguel, Marta, Jarrin-Vera, Inmaculada, González-García, Juan, GeSIDA 8514 Study Group |
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Přispěvatelé: | Instituto de Salud Carlos III, European Regional Development Fund, Plan Nacional de I+D+i (España), Red de Investigación Cooperativa en Investigación en Sida |
Rok vydání: | 2021 |
Předmět: |
Hepatitis B virus
medicine.medical_specialty Cirrhosis Epidemiology Human immunodeficiency virus (HIV) Patient characteristics HIV Infections medicine.disease_cause 03 medical and health sciences Hepatitis delta virus 0302 clinical medicine hepatitis delta virus HIV/HBV coinfection Virology Internal medicine HBV therapy Prevalence medicine Humans 030212 general & internal medicine biology Coinfection business.industry Research Public Health Environmental and Occupational Health virus diseases Hepatitis B medicine.disease digestive system diseases Europe Cross-Sectional Studies Spain biology.protein 030211 gastroenterology & hepatology Hepatitis D virus Antibody business Transient elastography HBV therapy HIV/HBV coinfection hepatitis delta virus |
Zdroj: | Repisalud Instituto de Salud Carlos III (ISCIII) Eurosurveillance r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante |
ISSN: | 1560-7917 1025-496X |
Popis: | Background Recent and reliable estimates on the prevalence of coinfection with human immunodeficiency virus (HIV) and hepatitis B virus (HBV) in Europe are lacking. Aim Leveraged on a study designed to assess HIV/HCV coinfection prevalence, we assessed the prevalence of HIV/HBV coinfection in Spain in 2018 and compared the results with five similar studies performed since 2002. Methods This cross-sectional prevalence study was carried out in 43 centres, and patients were selected using simple random sampling. The reference population comprised 40,322 patients and the sample size were 1,690 patients. Results The prevalence of HIV/HBV coinfection in Spain at the end of 2018 was 3.2%. The prevalence in 2002, 2009, 2015, 2016 and 2017 was 4.9%, 3.4%, 3%, 3.9% and 3%, respectively. Among the HIV/HBV-coinfected patients identified in 2018, 16.7% had cirrhosis according to transient elastography and 26.3% tested positive for antibodies against hepatitis D virus. All HIV/HBV-coinfected patients were receiving drugs with activity against HBV, and 97% of those tested for HBV DNA had an HBV DNA load Conclusions The prevalence of HIV/HBV coinfection in Spain remained stable at around 3% for a decade. Our data could facilitate the design of national programmes to control HBV infection and help identify areas of patient management that need improvement. |
Databáze: | OpenAIRE |
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