Inhibitory killer cell immunoglobulin-like receptors strengthen CD8 + T cell–mediated control of HIV-1, HCV, and HTLV-1
| Autor: | Ying Qi, Chrissy h. Roberts, Sharyne M. Donfield, Becca Asquith, Gregory D. Kirk, Simon Kollnberger, John Trowsdale, Julia Makinde, Jacquie Astemborski, Jyothi Jayaraman, David Price, Bisrat J Debebe, James A. Traherne, Kelly L. Miners, Kristin Ladell, Susan Buchbinder, Marcos Silveira, Jill Gilmour, Maureen P. Martin, Derek C. Macallan, Eddie Cy Wang, James J. Goedert, Arafa Salam, Salim I. Khakoo, Lies Boelen, Katie Twigger, John Frater, Chloe L. Thio, Mary Carrington |
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| Přispěvatelé: | Imperial College London, Universidade Estadual Paulista (Unesp), University of London, International AIDS Vaccine Initiative Human Immunology Laboratory, London School of Hygiene and Tropical Medicine, Cardiff University School of Medicine, University of Oxford, Oxford NIHR Biomedical Research Centre, University of Cambridge, Frederick National Laboratory for Cancer Research, Johns Hopkins University, Rho, San Francisco Department of Public Health, University of Southampton, National Cancer Institute, MIT and Harvard, Boelen, Lies [0000-0003-3786-5545], Debebe, Bisrat [0000-0002-6551-5641], Makinde, Julia [0000-0002-9906-7437], Roberts, Chrissy H [0000-0003-1064-5980], Wang, Eddie CY [0000-0002-2243-4964], Frater, John [0000-0001-7163-7277], Ladell, Kristin [0000-0002-9856-2938], Traherne, James A [0000-0002-6003-8559], Price, David A [0000-0001-9416-2737], Martin, Maureen P [0000-0002-0990-3500], Macallan, Derek C [0000-0002-3014-7148], Thio, Chloe L [0000-0002-8851-8319], Kirk, Gregory [0000-0002-7829-1405], Khakoo, Salim I [0000-0002-4057-9091], Goedert, James J [0000-0001-6134-1472], Carrington, Mary [0000-0002-2692-2180], Kollnberger, Simon [0000-0002-6904-3397], Asquith, Becca [0000-0002-5911-3160], Apollo - University of Cambridge Repository, Commission of the European Communities, Wellcome Trust, Medical Research Council (MRC) |
| Rok vydání: | 2018 |
| Předmět: |
HLA CLASS-I
EXPRESSION 0301 basic medicine GENES HUMAN-LEUKOCYTE-ANTIGEN T cell Immunology TYPE-1 INFECTION chemical and pharmacologic phenomena Hepacivirus Human leukocyte antigen CD8-Positive T-Lymphocytes 03 medical and health sciences 0302 clinical medicine Receptors KIR medicine Humans Cytotoxic T cell Receptor Human T-lymphotropic virus 1 Science & Technology Innate immune system biology DEATH RECOGNITION General Medicine biology.organism_classification 3. Good health AIDS 030104 developmental biology medicine.anatomical_structure HIV-1 biology.protein LIGANDS Antibody Life Sciences & Biomedicine CD8 RESPONSES 030215 immunology |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Science Immunology |
| ISSN: | 2470-9468 |
| DOI: | 10.1126/sciimmunol.aao2892 |
| Popis: | Made available in DSpace on 2019-10-06T16:55:02Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-01-01 Wisconsin Turfgrass Association National Institutes of Health Wellcome Trust Institute for National Strategic Studies Leukemia and Lymphoma Research Seventh Framework Programme Horizon 2020 Medical Research Council Canada National Institute on Drug Abuse National Institute of Child Health and Human Development Killer cell immunoglobulin-like receptors (KIRs) are expressed predominantly on natural killer cells, where they play a key role in the regulation of innate immune responses. Recent studies show that inhibitory KIRs can also affect adaptive T cell–mediated immunity. In mice and in human T cells in vitro, inhibitory KIR ligation enhanced CD8+ T cell survival. To investigate the clinical relevance of these observations, we conducted an extensive immunogenetic analysis of multiple independent cohorts of HIV-1–, hepatitis C virus (HCV)–, and human T cell leukemia virus type 1 (HTLV-1)–infected individuals in conjunction with in vitro assays of T cell survival, analysis of ex vivo KIR expression, and mathematical modeling of host-virus dynamics. Our data suggest that functional engagement of inhibitory KIRs enhances the CD8+ T cell response against HIV-1, HCV, and HTLV-1 and is a significant determinant of clinical outcome in all three viral infections. Department of Medicine Imperial College London Faculty of Engineering São Paulo State University—UNESP Institute for Infection and Immunity St. George’s University of London International AIDS Vaccine Initiative Human Immunology Laboratory Clinical Research Department London School of Hygiene and Tropical Medicine Divi-sion of Infection and Immunity Cardiff University School of Medicine Nuffield Department of Medicine University of Oxford Oxford NIHR Biomedical Research Centre Immunology Division Department of Pathology University of Cambridge Cancer and Inflammation Program Leidos Biomedical Research Inc. Frederick National Laboratory for Cancer Research Johns Hopkins University Rho San Francisco Department of Public Health Faculty of Medicine University of Southampton Division of Cancer Epidemiology and Genetics National Cancer Institute Ragon Institute of MGH, MIT and Harvard Faculty of Engineering São Paulo State University—UNESP Wisconsin Turfgrass Association: 090323/Z/09/Z National Institutes of Health: 100326Z/12/Z Wellcome Trust: 103865Z/14/Z Institute for National Strategic Studies: 105609/Z/14/Z Leukemia and Lymphoma Research: 15012 Seventh Framework Programme: 317040 Horizon 2020: 695551 Medical Research Council Canada: G1001052 Medical Research Council Canada: J007439 National Institute on Drug Abuse: K24-AI118591 Medical Research Council Canada: MR/L018373/L Medical Research Council Canada: MR/M019829/1 Medical Research Council Canada: MR/P001602/1 National Institutes of Health: R01 DA13324 National Institute on Drug Abuse: R01-DA-12568 National Institute of Child Health and Human Development: R01-HD-41224 National Institute on Drug Abuse: U01-DA-036297 |
| Databáze: | OpenAIRE |
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