NMDA NR2B subtype-selective receptor antagonists fail to antagonize electrically-precipitated seizures and elicit popping in mice
| Autor: | Jessica A. Burket, Richard B. Rosse, John Mastropaolo, Elionora Katz, Stephen I. Deutsch |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
Pharmacology Electroshock Dose-Response Relationship Drug Hindlimb Subtype selective Receptors N-Methyl-D-Aspartate Tonic (physiology) Mice Psychiatry and Mental health chemistry.chemical_compound Phenols Piperidines Neurology chemistry Seizures Ifenprodil Animals NMDA receptor Pharmacology (medical) Neurology (clinical) Receptor Biological Psychiatry |
| Zdroj: | European Neuropsychopharmacology. 20:207-210 |
| ISSN: | 0924-977X |
| Popis: | NR2B-subtype-selective antagonists differ from MK-801, a nonselective NMDA receptor antagonist. MK-801 antagonizes electrical seizures at doses as low as 0.1 to 0.18 mg/kg and elicits popping at doses as low as 0.5 mg/kg, whereas ifenprodil and Ro 8-4304 were unable to do so at the doses tested. Ro 25-6981, however, was able to antagonize electrically-precipitated tonic hindlimb extension at 100 mg/kg, but was not able to elicit popping behavior at this dose. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect