The Level of Cytokines in the Vitreous Body of Severe Proliferative Diabetic Retinopathy Patients Undergoing Posterior Vitrectomy
| Autor: | Krystyna Raczyńska, Dorota Raczyńska, Krzysztof Pietruczuk, Leopold Glasner, Jacek M. Witkowski, Joanna Borucka, Mateusz Ślizień, Katarzyna A. Lisowska |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Pars plana medicine.medical_specialty Intraocular pressure Visual acuity genetic structures medicine.medical_treatment Vitrectomy Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Ophthalmology Drug Discovery medicine Humans Aflibercept Pharmacology Diabetic Retinopathy business.industry Diabetic retinopathy Middle Aged medicine.disease eye diseases Vitreous Body 030104 developmental biology medicine.anatomical_structure 030221 ophthalmology & optometry Cytokines Female sense organs medicine.symptom business medicine.drug |
| Zdroj: | Current Pharmaceutical Design. 24:3276-3281 |
| ISSN: | 1381-6128 |
| DOI: | 10.2174/1381612824666180926110704 |
| Popis: | Objective: The objective of the study was to compare cytokine levels in the vitreous body of patients with proliferative diabetic retinopathy (PDR) undergoing posterior vitrectomy. Patients and methods: The study included 39 patients (39 eyes) undergoing pars plana vitrectomy (PPV). Patients were divided into three groups: patients with proliferative diabetic retinopathy (PDR) without aflibercept injection prior to the surgery, PDR patients administered aflibercept injection prior to the surgery, and patients without diabetes mellitus (control group). All patients underwent a comprehensive eye examination one day before and 3 weeks after the surgery, including measurements of: best-corrected visual acuity (BVCA) and intraocular pressure (IOP), slit-lamp examination and spectral domain optical coherence tomography (SOCT). Concentrations of cytokines: IL-6, IL-8, IL-12p70, TNF, IL-10, IL-1β were measured in the vitreous body of patients with BD™ Cytometric Bead Array (CBA) Human Inflammatory Cytokines Kit. Results: PDR patients who received pretreatment with aflibercept injection showed significantly lower concentrations of IL-12p70, TNF, IL-10 and IL-1β in the vitreous body compared to the control group. Meanwhile, patients without prior aflibercept injection had a significantly higher concentration of IL-8. There was also a significant positive correlation between IOP before PPV and IL-8 concentration in both PDR patients’ groups. Conclusion: Findings of our study suggest an important role of IL-8 in the development of severe PDR. Aflibercept administration on the day before elective vitrectomy facilitated the surgery. |
| Databáze: | OpenAIRE |
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