Acute Immune Signatures and Their Legacies in Severe Acute Respiratory Syndrome Coronavirus-2 Infected Cancer Patients
| Autor: | Sheeba Irshad, Paul Fields, Doraid Alrifai, Richard Davis, Yin Wu, Isaac Francos Quijorna, Anna Lorenc, Eva Bugallo-Blanco, Julie Nuo En Chan, Anne Rigg, Jennifer Vidler, Adrian Hayday, Aadil A. Khan, Julien de Naurois, Charlotte Moss, Sultan Abdul-Jawad, Pierre Vantourout, Louisa Mcdonald, Duncan R. McKenzie, Mieke Van Hemelrijck, Paul R. Barber, Irene del Molino del Barrio, Sophie Papa, Katharine Bailey, Deborah Enting, Beth Russell, Sophie Hazell, Sarah Gee, Tony Ng, Sarah Ryan, You Zhou, Anthony C. C. Coolen, Iva Zlatareva, Piers E.M. Patten, Adam Laing, Sophia N. Karagiannis, Miguel Muñoz-Ruiz, Luca Bau, Thomas Hayday, Yadanar Lwin, Shraddha Kamdar, Matthew Fish, Reuben Benjamin, Rozalyn Yorke, Aislinn Jennings, Katie J. Doores, Mayur Kumar, Thanussuyah Alaguthurai, Leticia Monin, Mark Rowley, James Spicer |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Male Cancer Research viruses T-Lymphocytes medicine.disease_cause Severe Acute Respiratory Syndrome 0302 clinical medicine vaccine Nasopharynx Neoplasms Medicine antibodies Young adult Aged 80 and over education.field_of_study hemato-oncological biology Middle Aged Oncology 030220 oncology & carcinogenesis Hematologic Neoplasms Female Antibody Adult Population Article virus shedding Immunophenotyping 03 medical and health sciences Young Adult Immune system cancer Humans Viral shedding Seroconversion education seroconversion Aged business.industry SARS-CoV-2 Cancer COVID-19 Cell Biology Immune dysregulation medicine.disease 030104 developmental biology Immunology biology.protein immune business |
| Zdroj: | Cancer Cell |
| ISSN: | 1535-6108 |
| DOI: | 10.1016/j.ccell.2021.01.001 |
| Popis: | Given the immune system's importance for cancer surveillance and treatment, we have investigated how it may be affected by SARS-CoV-2 infection of cancer patients. Across some heterogeneity in tumor type, stage, and treatment, virus-exposed solid cancer patients display a dominant impact of SARS-CoV-2, apparent from the resemblance of their immune signatures to those for COVID-19+ non-cancer patients. This is not the case for hematological malignancies, with virus-exposed patients collectively displaying heterogeneous humoral responses, an exhausted T cell phenotype and a high prevalence of prolonged virus shedding. Furthermore, while recovered solid cancer patients' immunophenotypes resemble those of non-virus-exposed cancer patients, recovered hematological cancer patients display distinct, lingering immunological legacies. Thus, while solid cancer patients, including those with advanced disease, seem no more at risk of SARS-CoV-2-associated immune dysregulation than the general population, hematological cancer patients show complex immunological consequences of SARS-CoV-2 exposure that might usefully inform their care. Graphical Abstract Following SARS-Cov-2 infection, Sultan et al. showed that the majority of solid cancer patients cleared virus, recovered from COVID-19, and re-established their prior immunological status. In contrast, hematological cancer patients demonstrated delayed or negligible seroconversion, prolonged shedding, and sustained immune dysregulation highlighting the need for careful oversight of these patients. |
| Databáze: | OpenAIRE |
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