Radiation therapy for feline cutaneous squamous cell carcinoma using a hypofractionated protocol
| Autor: | Paulo Cesar Canary, Ana Maria Reis Ferreira, Márcio Lemberg Reisner, Heloisa J.M. Souza, K. B. Corgozinho, Luís Alfredo V. de Carvalho, Simone Carvalho dos Santos Cunha |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Skin erythema Skin Neoplasms medicine.medical_treatment Cat Diseases medicine Carcinoma Animals Small Animals Adverse effect Neoplasm Staging CATS business.industry Histology Dose-Response Relationship Radiation medicine.disease Surgery Radiation therapy Treatment Outcome Toxicity Carcinoma Squamous Cell Cats Female Radiology Dose Fractionation Radiation business Bolus (radiation therapy) |
| Zdroj: | Journal of feline medicine and surgery. 12(4) |
| ISSN: | 1532-2750 |
| Popis: | The objective of this paper was to evaluate the efficacy of a hypofractionated radiation protocol for feline facial squamous cell carcinoma (SCC). Twenty-five histologically confirmed SCCs in 15 cats were treated with four fractions of 7.6–10 Gy each, with 1 week intervals. The equipment used was a linear accelerator Clinac 2100 delivering electron beam of 4 or 6 MeV, and a bolus of 5 or 10 mm was used in all lesions. Of the lesions, 44% were staged as T4, 16% as T3, 8% as T2 and 32% as T1. Of the irradiated lesions, 40% had complete response, 12% had partial response and 48% had no response (NR) to the treatment. For T1 tumors, 62.5% had complete remission. Mean overall survival time was 224 days. Owners requested euthanasia of cats having NR to the treatment. Mean disease free time was 271 days. Side effects observed were skin erythema, epilation, ulceration and conjunctivitis, which were graded according to Veterinary Radiation Therapy Oncology Group (VRTOG) toxicity criteria. Response rates found in this study (52%) were lower when compared to other protocols, probably due to technique differences, such as fractionation schedule, bolus thickness and energy penetration depth. However, the hypofractionated radiation protocol was considered safe for feline facial SCC. Modifications of this protocol are being planned with the objective of improving the cure rates in the future. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|